4-chloro-2-(7-chloro-(4-dimethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol | 1430822-91-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-chloro-2-(7-chloro-(4-dimethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol
• 英文别名: 4-chloro-2-[7-chloro-4-(dimethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl]phenol
• CAS: 1430822-91-5
• 化学式: C₁₉H₁₅Cl₂N₃O₂
• 分子量: 388.253
• InChiKey: KJBAACSCVGBKHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  58.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  二甲胺 、 5-氯代水杨醛 、 6-chloro-2-imino-2H-chromene-3-carbonitrile 在 水 作用下， 反应 8.0h， 以77%的产率得到4-chloro-2-(7-chloro-(4-dimethylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol
  参考文献：
  名称：

  Novel Approaches for the Synthesis of a Library of Fluorescent Chromenopyrimidine Derivatives

  摘要：

  A library of some new fluorescent chromenopyrimidine derivatives has been synthesized by new approaches. Water-promoted and one-pot reaction can produce new dialkylylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl) phenols. These compounds can also be produced using domino reaction. Two parallel methods are compared. Novel N-alkyl-N-phenyl-5H-chromeno [2,3-d] -pyrimidin-4-amines and 4-alkoxy-5H-chromeno[2, 3-d]pyrimidines are synthesized by Lewis-acid catalyzed reactions. The fluorescence emission intensity of the four compounds from each of libraries after excitation in 290 nm is measured. Compound 2-(4,5-bis(N-methyl-N-phenylamino)-5H-chromeno[2,3-d]pyrimidin-2-yl)phenol was isolated as a byproduct. The details of an interesting exchangeable intramolecular H-bonding of two of the new compounds are reported by X-ray analysis data.

  DOI：

  10.1021/co300141j

文献信息

• Synthesis, Characterization, and Heterogeneous Catalytic Activity of Sulfamic Acid Functionalized Magnetic IRMOF‐3
  作者：Mohammad Mahdi Mostafavi、Farnaz Movahedi

  DOI：10.1002/ejic.201801054

  日期：2019.2.14

  In this work, post‐synthesis modification of Fe3O4/IRMOF‐3 nanocomposite with chlorosulfonic acid groups afforded sulfamic acid‐functionalized magnetic metal‐organic frameworks (Fe3O4/IRMOF‐3/SO3H). Functionalization was followed through FT‐IR, XRD, TGA, BET, FESEM/EDS and elemental analysis. The catalytic efficiency of the as‐prepared nanocomposite was evaluated through one‐pot pseudo four‐component

  在这项工作中，用氯磺酸基团对Fe 3 O 4 / IRMOF-3纳米复合材料进行合成后修饰提供了氨基磺酸官能化的磁性金属有机骨架（Fe 3 O 4 / IRMOF-3 / SO 3H）。通过FT-IR，XRD，TGA，BET，FESEM / EDS和元素分析进行​​功能化。在温和条件下，通过仲胺，丙二腈和水杨醛在EtOH中的一锅假四组分反应，评估了制备的纳米复合材料的催化效率。功能化IRMOF-3的磁化趋势使得可以在使用外部磁场的情况下从反应混合物中轻松倾析，随后催化剂至少可重复使用五次，而不会显着降低催化效率。
• Covalently anchored 2-amino ethyl-3-propyl imidazolium bromideon SBA-15 as a green, efficient and reusable Brønsted basic ionic liquid nanocatalyst for one-pot solvent-free synthesis of benzopyranopyrimidines under ultrasonic irradiation
  作者：Mina Jafari Nasab、Ali Reza Kiasat

  DOI：10.1039/c5ra11006h

  日期：——

  Preparation of benzopyranopyrimidine derivatives under ultrasonic irradiation, catalyzed by SBA-IM-NH₂.

  在超声辐射下，由SBA-IM-NH₂催化制备苯并吡啶并嘧啶衍生物。
• Silica nanoparticles immobilized benzoylthiourea ferrous complex as an efficient and reusable catalyst for one-pot synthesis of benzopyranopyrimidines
  作者：Sara Amirnejat、Farnaz Movahedi、Hassan Masrouri、Meysam Mohadesi、M.Z. Kassaee

  DOI：10.1016/j.molcata.2013.05.023

  日期：2013.11

  Benzoylthiourea Fe(II) complex was supported on silica nanoparticles and employed as a heterogeneous catalyst in preparation of benzopyranopyrimidines through one-pot condensation reaction of salicylaldehydes, malononitrile and secondary amines in EtOH, at room temperature. The prepared catalyst was characterized by BET, ICP, FT-IR, TGA, SEM-EDX, TEM and elemental analysis. The catalyst could be recovered easily and reused at least five times without significant loss of its catalytic activity (c) 2013 Elsevier B.V. All rights reserved.