1-[3-(7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethyl-phenyl)-urea | 1231736-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[3-(7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethyl-phenyl)-urea
• 英文别名: 1-[3-(7-pyridin-4-yl-2,3-dihydropyrazolo[5,1-b][1,3]thiazol-6-yl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
• CAS: 1231736-65-4
• 化学式: C₂₄H₁₈F₃N₅OS
• 分子量: 481.501
• InChiKey: JTTSUCMNFKZQHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  97.1
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-(7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenylamine 、 4-三氟甲基苯基异氰酸酯 在 氮气 、 crude product 、 silica gel 、 methanol-dichloromethane 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以to give 73 mg (86%) of 1-[3-(7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethyl-phenyl)-urea as white powder的产率得到1-[3-(7-pyridin-4-yl-2,3-dihydro-pyrazolo[5,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethyl-phenyl)-urea
  参考文献：
  名称：

  BICYCLIC PYRAZOLES AS PROTEIN KINASE INHIBITORS

  摘要：

  本文揭示了式（I）中定义的3,4-二芳基-双环吡唑衍生物及其药学上可接受的盐，以及其制备方法和包含它们的制药组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症方面有用。

  公开号：

  US20110257165A1

文献信息

• [EN] BICYCLIC PYRAZOLES AS PROTEIN KINASE INHIBITORS<br/>[FR] PYRAZOLES BICYCLIQUES EN TANT QU'INHIBITEURS DE PROTÉINES KINASES
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2010070060A1

  公开（公告）日：2010-06-24

  3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  公开了规范中定义的式(I)的3,4-二芳基-双环吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物；发明的化合物可能在治疗中对治疗与蛋白激酶活性失调相关的疾病，如癌症，具有用处。
• BICYCLIC PYRAZOLES AS PROTEIN KINASE INHIBITORS
  申请人：Pulici Maurizio

  公开号：US20110257165A1

  公开（公告）日：2011-10-20

  3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本文揭示了式（I）中定义的3,4-二芳基-双环吡唑衍生物及其药学上可接受的盐，以及其制备方法和包含它们的制药组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症方面有用。
• US8524707B2
  申请人：——

  公开号：US8524707B2

  公开（公告）日：2013-09-03
• Bicyclic pyrazoles as protein kinase inhibitors
  申请人：Pulici Maurizio

  公开号：US08524707B2

  公开（公告）日：2013-09-03

  3,4-diaryl-bicyclicpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本发明揭示了公式（I）中定义的3,4-二芳基双环吡唑衍生物及其药学上可接受的盐，以及它们的制备方法和包括它们的制药组合物；本发明的化合物可能在治疗与蛋白激酶活性失调有关的疾病，如癌症方面有用。