4-acetylaminoacetophenyl DO3A | 1073754-95-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetylaminoacetophenyl DO3A
• 英文别名: Ac-Aad
• CAS: 1073754-95-6
• 化学式: C₂₄H₃₅N₅O₈
• 分子量: 521.571
• InChiKey: MFEPREROJLWJGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  37.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  171.03
• 氢给体数：
  4.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  4-acetylaminoacetophenyl DO3A tert-butyl ester 在 三氟乙酸 作用下， 反应 12.0h， 以27%的产率得到4-acetylaminoacetophenyl DO3A
  参考文献：
  名称：

  Lanthanide-Based Protease Activity Sensors for Time-Resolved Fluorescence Measurements

  摘要：

  Lanthanide-based luminescent sensors are noteworthy because their long-lifetime luminescence enables time-resolved fluorescence measurements. After exploring suitable antenna groups, we designed and synthesized lanthanide-based luminogenic sensors detecting protease activities. This sensor yielded strong luminescence on addition of proteases such as calpain I and leucine aminopeptidase (LAP). Since the luminescence lifetimes of the probes were very long, the sensors could be applied to time-resolved measurements that exclude background fluorescence signals derived from protiens or other impurities. This sensing principle could be applicable to general time-resolved fluorescence assays for other proteases.

  DOI：

  10.1021/ja800322b