2-[[5-(1-methylpyrazol-4-yl)pyridin-2-yl]methyl]-3H-isoindol-1-one | 1432436-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[[5-(1-methylpyrazol-4-yl)pyridin-2-yl]methyl]-3H-isoindol-1-one
• CAS: 1432436-77-5
• 化学式: C₁₈H₁₆N₄O
• 分子量: 304.351
• InChiKey: JHIOUOBEMLJWTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1<br/>[FR] ANALOGUES SUBSTITUES 2-(4-HETEROCYCLYLBENZYLE)ISOINDOLINE-1-UN EMPLOYES COMME MODULATEURS ALLOSTERIQUES POSITIFS DU RECEPTEUR M1 ACETYLCHOLINE MUSCARINIQUE
  申请人：UNIV VANDERBILT

  公开号：WO2013063549A1

  公开（公告）日：2013-05-02

  In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin- 1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及替代2-(4-杂环基苯基)异吲哚啉-1-酮类似物化合物，其衍生物以及相关化合物，这些化合物可用作肌胆碱受体M1（mAChR M1）的正向变构调节剂；制备这些化合物的合成方法；含有这些化合物的药物组合物；以及使用这些化合物和组合物治疗与肌胆碱受体功能障碍相关的神经和精神疾病的方法。本摘要旨在作为在特定领域搜索的扫描工具，并不旨在限制本发明。
• SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1
  申请人：Lindsley Craig W.

  公开号：US20140288084A1

  公开（公告）日：2014-09-25

  In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本发明涉及取代的2-(4-杂环基苯基)异吲哚啉-1-酮类似物化合物、其衍生物和相关化合物，其作为肌动蛋白乙酰胆碱受体M1(mAChR M1)的正向变构调节剂具有用途；制备这些化合物的合成方法；包括这些化合物的药物组合物；以及使用这些化合物和组合物治疗与肌动蛋白乙酰胆碱受体功能障碍相关的神经和精神障碍的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
  申请人：Vanderbilt University

  公开号：US10654847B2

  公开（公告）日：2020-05-19

  In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及取代的2-(4-杂环苄基)异吲哚啉-1-酮类似物化合物、其衍生物和相关化合物，这些化合物可用作毒蕈碱乙酰胆碱受体M1(mAChR M1)的正异位调节剂；制造这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与毒蕈碱乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本发明的限制。
• US9586964B2
  申请人：——

  公开号：US9586964B2

  公开（公告）日：2017-03-07