5,11,17,23-tetra-tert-butyl-25,27-bis[[3-(2-propynyloxy)benzyl]oxy]calix[4]arene-26,28-diol | 176038-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5,11,17,23-tetra-tert-butyl-25,27-bis[[3-(2-propynyloxy)benzyl]oxy]calix[4]arene-26,28-diol
• 英文别名: 5,11,17,23-Tetratert-butyl-26,28-bis[(3-prop-2-ynoxyphenyl)methoxy]pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene-25,27-diol
• CAS: 176038-89-4
• 化学式: C₆₄H₇₂O₆
• 分子量: 937.272
• InChiKey: OCSCNAJKGHBEJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.8
• 重原子数：
  70
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5,11,17,23-tetra-tert-butyl-25,27-bis[[3-(2-propynyloxy)benzyl]oxy]calix[4]arene-26,28-diol 在 吡啶 、 copper diacetate 、 氧气 作用下， 以 丙酮 为溶剂， 以75%的产率得到28,34,40,45-Tetratert-butyl-3,10,17,24-tetraoxaoctacyclo[24.15.7.15,9.118,22.132,36.143,47.02,38.025,30]dopentaconta-1,5(52),6,8,18,20,22(51),25,27,29,32(50),33,35,38,40,43,45,47(49)-octadecaen-12,14-diyne-49,50-diol
  参考文献：
  名称：

  Selective Upper Rim Functionalization and Lower Rim Bridge Building with Calix[4]arenes and Calix[6]arenes¹

  摘要：

  Selective upper rim functionalization of calix[6]arenes has been achieved by selective lower rim benzoylation at the 1,2,4,5 positions followed by AlCl3-induced removal of the tert-butyl groups of the unesterified aryl residues and introduction of various functionalities into the vacated para positions, including bromo (5), dialkylamino, (7-11) cyanomethyl (12), and (propargyloxy)methyl (13) groups. Lower rim bridge building has been achieved via oxidative coupling reactions between the aryne moieties of calix[4]arenes and calix[6]arenes in which O-benzyl groups carry one (from 23 and 24) or two (from 25) propargyloxy residues. In the calix[4]arene series both a single-spanned (32) and a double-spanned (33) double-cavity calixarene were obtained. In the calix[6]arene series only a single-spanned double cavity calixarene (36) could be characterized.

  DOI：

  10.1021/jo952054a
• 作为产物：
  描述：

  Prop-2-ynyl 3-prop-2-ynoxybenzoate 在 lithium aluminium tetrahydride 、 potassium carbonate 、 三乙胺 、 lithium bromide 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 11.0h， 生成 5,11,17,23-tetra-tert-butyl-25,27-bis[[3-(2-propynyloxy)benzyl]oxy]calix[4]arene-26,28-diol
  参考文献：
  名称：

  Selective Upper Rim Functionalization and Lower Rim Bridge Building with Calix[4]arenes and Calix[6]arenes¹

  摘要：

  Selective upper rim functionalization of calix[6]arenes has been achieved by selective lower rim benzoylation at the 1,2,4,5 positions followed by AlCl3-induced removal of the tert-butyl groups of the unesterified aryl residues and introduction of various functionalities into the vacated para positions, including bromo (5), dialkylamino, (7-11) cyanomethyl (12), and (propargyloxy)methyl (13) groups. Lower rim bridge building has been achieved via oxidative coupling reactions between the aryne moieties of calix[4]arenes and calix[6]arenes in which O-benzyl groups carry one (from 23 and 24) or two (from 25) propargyloxy residues. In the calix[4]arene series both a single-spanned (32) and a double-spanned (33) double-cavity calixarene were obtained. In the calix[6]arene series only a single-spanned double cavity calixarene (36) could be characterized.

  DOI：

  10.1021/jo952054a