(E)-1-[2-(pyridin-4-yl)vinyl]-(E)-4-[4-di(1-butyl)aminostyryl]-2,5-bis(phenylethynyl)benzene | 1196586-04-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (E)-1-[2-(pyridin-4-yl)vinyl]-(E)-4-[4-di(1-butyl)aminostyryl]-2,5-bis(phenylethynyl)benzene
• 英文别名: 4-[(E)-2-[2,5-bis(2-phenylethynyl)-4-[(E)-2-pyridin-4-ylethenyl]phenyl]ethenyl]-N,N-dibutylaniline
• CAS: 1196586-04-5
• 化学式: C₄₅H₄₂N₂
• 分子量: 610.842
• InChiKey: QRCLQHCBTNAQDS-FQHZWJPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.1
• 重原子数：
  47
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-1-[2-(pyridin-4-yl)vinyl]-(E)-4-[4-di(1-butyl)aminostyryl]-2,5-diiodobenzene 、 苯乙炔 在 哌啶 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 以84%的产率得到(E)-1-[2-(pyridin-4-yl)vinyl]-(E)-4-[4-di(1-butyl)aminostyryl]-2,5-bis(phenylethynyl)benzene
  参考文献：
  名称：

  Unsymmetrical Cruciforms

  摘要：

  Five new, unsymmetrical 1,4-distyryl-2,5-bisphenylethynylbenzenes (cruciforms, XF) have been prepared by a sequential Horner reaction of the bisphosphonate of 2,5-diiodo-1,4-xylene with two different aromatic aldehydes. The obtained diiodide was coupled to phenylacctylene under Sonogashira conditions with (Ph3P)(2)PdCl2 as catalyst. The resulting XFs carry dibutylamino, pyridyl, cyano, and diphenylamino residues on their styryl arms to give rise to donor(-), acceptor(-), and donor(-)acceptor-substituted XFs. The optical properties of these XFs were investigated. Titration studies using trifluoroacetic acid tracked changes in the electronic structure of the XFs upon protonation. Donor XFs display a blue shift in absorption and emission upon protonation, while the pyridyl-substituted XF displays red shift in absorption and emission upon protonation. In the case of the donor(-)acceptor XF carrying a pyridyl and an aminostyryl arm, the first protonation occurs either oil the pyridine or oil the dibutylamino arm; a red shift is seen in absorption (for the former) and a blue Shift is observed in emission (for the latter). The titration studies indicate that the protonated XFs do not display kinetic photoacidity when operating either in dichloromethane or acetonitrile solutions. The trends observed for protonation were mirrored when the XFs bind to metal cations. While the binding constants of the metal cations to the XFs were lower than for that for protons, as in some cases full metalation of the XF could not be obtained, the results were qualitatively the same. We did not find dynamic excited-state decomplexation events in the XFs that we have investigated. The XFs, stilbene derivatives, are different from other reported, similarly structured fluorophores as they show significant ratiometric changes in emission upon metal complexation; thus, distyrylbenzene-derived fluorophores may be, in the end, viable choices as platforms for metal ion detection.

  DOI：

  10.1021/jo901961a

文献信息

• Unsymmetrical Cruciforms
  作者：Juan Tolosa、Kyril M. Solntsev、Laren M. Tolbert、Uwe H. F. Bunz

  DOI：10.1021/jo901961a

  日期：2010.2.5

  Five new, unsymmetrical 1,4-distyryl-2,5-bisphenylethynylbenzenes (cruciforms, XF) have been prepared by a sequential Horner reaction of the bisphosphonate of 2,5-diiodo-1,4-xylene with two different aromatic aldehydes. The obtained diiodide was coupled to phenylacctylene under Sonogashira conditions with (Ph3P)(2)PdCl2 as catalyst. The resulting XFs carry dibutylamino, pyridyl, cyano, and diphenylamino residues on their styryl arms to give rise to donor(-), acceptor(-), and donor(-)acceptor-substituted XFs. The optical properties of these XFs were investigated. Titration studies using trifluoroacetic acid tracked changes in the electronic structure of the XFs upon protonation. Donor XFs display a blue shift in absorption and emission upon protonation, while the pyridyl-substituted XF displays red shift in absorption and emission upon protonation. In the case of the donor(-)acceptor XF carrying a pyridyl and an aminostyryl arm, the first protonation occurs either oil the pyridine or oil the dibutylamino arm; a red shift is seen in absorption (for the former) and a blue Shift is observed in emission (for the latter). The titration studies indicate that the protonated XFs do not display kinetic photoacidity when operating either in dichloromethane or acetonitrile solutions. The trends observed for protonation were mirrored when the XFs bind to metal cations. While the binding constants of the metal cations to the XFs were lower than for that for protons, as in some cases full metalation of the XF could not be obtained, the results were qualitatively the same. We did not find dynamic excited-state decomplexation events in the XFs that we have investigated. The XFs, stilbene derivatives, are different from other reported, similarly structured fluorophores as they show significant ratiometric changes in emission upon metal complexation; thus, distyrylbenzene-derived fluorophores may be, in the end, viable choices as platforms for metal ion detection.