1-(4-(5-bromothiazol-2-yl)phenyl)ethanone | 810662-43-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(5-bromothiazol-2-yl)phenyl)ethanone
• 英文别名: Ethanone, 1-[4-(5-bromo-2-thiazolyl)phenyl]-；1-[4-(5-bromo-1,3-thiazol-2-yl)phenyl]ethanone
• CAS: 810662-43-2
• 化学式: C₁₁H₈BrNOS
• 分子量: 282.161
• InChiKey: VLKASLAMPHOPRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL S1P RECEPTOR MODULATING AGENT
  申请人：MEIJI SEIKA PHARMA CO., LTD.

  公开号：US20130217663A1

  公开（公告）日：2013-08-22

  An object of the present invention is to provide a compound having a modulating activity at an S1P receptor which is useful for preventing and treating autoimmune diseases, allergic diseases, and the like. According to the present invention, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof is provided.

  本发明的一个目的是提供一种具有S1P受体调节活性的化合物，该化合物对于预防和治疗自身免疫疾病、过敏性疾病等是有用的。根据本发明，提供了一种由式(I)表示的化合物或其药学上可接受的盐。
• Compounds and uses thereof in modulating amyloid beta
  申请人：Cheng Soan

  公开号：US20050070538A1

  公开（公告）日：2005-03-31

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物，组合物和试剂盒。还提供了调节Aβ水平的方法，以及治疗与异常Aβ水平相关的疾病的方法。
• COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
  申请人：Cheng Soan

  公开号：US20070249833A1

  公开（公告）日：2007-10-25

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  提供了新型化合物、组合物和试剂盒。还提供了调节Aβ水平的方法和治疗与异常Aβ水平相关的疾病的方法。
• Compounds and Uses Thereof in Modulating Amyloid Beta
  申请人：Cheng Soan

  公开号：US20070260058A1

  公开（公告）日：2007-11-08

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物、组合物和试剂盒。还提供了调节Aβ水平的方法以及治疗与异常Aβ水平相关的疾病的方法。
• ALPHA-HALOKETONE DERIVATIVES OF IMIDAZOLYL-SUBSTITUTED AROMATIC COMPOUNDS AND COMPOUNDS PREPARED THEREFROM
  申请人：Cheng Soan

  公开号：US20100331551A1

  公开（公告）日：2010-12-30

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物、组合物和试剂盒。还提供了调节Aβ水平的方法，以及治疗与异常Aβ水平相关的疾病的方法。