Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride | 1219204-23-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride
• 英文别名: 1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole-3-carboxylic acid;hydrochloride
• CAS: 1219204-23-5
• 化学式: C8H14ClNO2
• mdl: MFCD20039926
• 分子量: 191.65
• InChiKey: MIIHGYVJEBVNQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.86
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  49.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION
  申请人：Holsinger Leslie Jean

  公开号：US20090270415A1

  公开（公告）日：2009-10-29

  The present invention is directed to compounds that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.

  本发明涉及具有双重性质的化合物，既具有作为蛋白酶S抑制剂的作用，又具有抑制HCV复制的作用。因此，这些化合物对治疗包括丙型肝炎、阿尔茨海默病和自身免疫性疾病等疾病状态有用。本发明还涉及含有这些化合物的制药组合物以及制备这些化合物的过程。
• BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
  申请人：Codexis, Inc.

  公开号：EP2307419A2

  公开（公告）日：2011-04-13
• US8106059B2
  申请人：——

  公开号：US8106059B2

  公开（公告）日：2012-01-31
• [EN] COMPOUNDS THAT INHIBIT PROTEASE CATHEPSIN S AND HCV REPLICATION<br/>[FR] COMPOSÉS CAPABLES D'INHIBER LA PROTÉASE CATHEPSINE S ET LA RÉPLICATION DU HCV
  申请人：VIROBAY INC

  公开号：WO2009055467A2

  公开（公告）日：2009-04-30

  The present invention is directed to compounds that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.
• [EN] BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS<br/>[FR] PROCÉDÉS BIOCATALYTIQUES POUR LA PRÉPARATION DE COMPOSÉS DE PROLINE BICYCLIQUES CONDENSÉS SENSIBLEMENT PURS SUR LE PLAN STÉRÉO-ISOMÉRIQUE
  申请人：CODEXIS INC

  公开号：WO2010008828A2

  公开（公告）日：2010-01-21

  The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.