| 1033190-46-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• CAS: 1033190-46-3
• 化学式: C₁₂H₂₄NO₄P
• 分子量: 277.301
• InChiKey: OMYPEOHWESWXJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.65
• 重原子数：
  18.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.84
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  α-diazo-α-(diethoxyphosphoryl)-N,N-(diisopropyl)acetamide 以 正己烷 为溶剂， 反应 23.0h， 以63%的产率得到3-(diethoxyphosphoryl)-1-isopropyl-4,4-dimethyl-β-lactam
  参考文献：
  名称：

  C−H Carbene Insertion of α-Diazo Acetamides by Photolysis in Non-Conventional Media

  摘要：

  Light from a mercury vapor high-pressure lamp was used to induce the photolytic decomposition of alpha-diazo acetamides in hexane and in nonconventional media such as water or a film. The corresponding beta- and/or gamma-lactams were obtained in reasonable yields and in some cases with good diastereoselectivities with no need to use a metallic catalyst. Experimental studies on chiral substrates demonstrated the occurrence of insertion with retention of configuration.

  DOI：

  10.1021/jo800980c