3-[(2-fluoro-4-iodophenyl)amino]-5-[3-(propionylamino)phenoxy]isonicotinamide | 1373870-82-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[(2-fluoro-4-iodophenyl)amino]-5-[3-(propionylamino)phenoxy]isonicotinamide
• 英文别名: 3-(2-Fluoro-4-iodoanilino)-5-[3-(propanoylamino)phenoxy]pyridine-4-carboxamide
• CAS: 1373870-82-6
• 化学式: C₂₁H₁₈FIN₄O₃
• 分子量: 520.302
• InChiKey: AZTKDKPPFOICQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED PHENOXYPYRIDINES<br/>[FR] PHÉNOXYPYRIDINES SUBSTITUÉES
  申请人：BAYER PHARMA AG

  公开号：WO2012055953A1

  公开（公告）日：2012-05-03

  The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式（I）中R1、R2和R3如声明中定义的取代苯氧吡啶化合物，以制备所述化合物的方法，用于制备药物组合物和组合物，以及用于制造治疗或预防疾病的药物组合物的制备中使用所述化合物，特别是用于治疗或预防增殖过度和/或血管生成障碍的疾病，作为唯一的制剂或与其他活性成分组合使用。
• SUBSTITUTED PHENOXYPYRIDINES
  申请人：Hitchcock Marion

  公开号：US20130252922A1

  公开（公告）日：2013-09-26

  The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及通式（I）中R1、R2和R3如权利要求中所定义的取代苯氧基吡啶化合物，以制备该化合物的方法，制备该化合物的中间体，包含该化合物的制药组合物和组合物，以及使用该化合物制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的制药组合物的方法，作为单一制剂或与其他活性成分组合使用。
• US9045429B2
  申请人：——

  公开号：US9045429B2

  公开（公告）日：2015-06-02