4-(2-Deuterioethyl)-4-hydroxy-1,6-heptadiene | 86816-18-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-Deuterioethyl)-4-hydroxy-1,6-heptadiene
• 英文别名: 4-(2-Deuterioethyl)hepta-1,6-dien-4-ol
• CAS: 86816-18-4
• 化学式: C₉H₁₆O
• 分子量: 141.218
• InChiKey: ZNYOYPXOCNWHCW-WFVSFCRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-氯丙酰氯 、 烯丙基溴化镁 生成 4-(2-Deuterioethyl)-4-hydroxy-1,6-heptadiene
  参考文献：
  名称：

  γ-Substituted Organoalkali Compounds; Preparation and Synthetic Applications

  摘要：

  DOI：

  10.1055/s-1983-30342

文献信息

• Direct coupling of functionalized organolithium compounds with aryl and vinyl halides
  作者：Jose Barluenga、Javier M. Montserrat、Josefa Florez

  DOI：10.1021/jo00074a025

  日期：1993.10

  The reaction between beta- and gamma-nitrogen-functionalized and gamma- and epsilon-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37. Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene. The formation of alkyl halides as intermediates has been verified. Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.