5-Chloro-4-oxopentanoyl chloride | 522648-63-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Chloro-4-oxopentanoyl chloride
• CAS: 522648-63-1
• 化学式: C₅H₆Cl₂O₂
• 分子量: 169.0
• InChiKey: PDERGHFHIOCEML-UHFFFAOYSA-N

物化性质

• 沸点：
  234.9±20.0 °C(Predicted)
• 密度：
  1.319±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• GENETICALLY-ENCODED BICYCLIC PEPTIDE LIBRARIES
  申请人：The Governors of the University of Alberta

  公开号：EP3827116A1

  公开（公告）日：2021-06-02
• NOVEL DIHYDROISOXAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HEPATITIS B
  申请人：Novartis AG

  公开号：US20210079015A1

  公开（公告）日：2021-03-18

  The invention provides compounds of Formula (I) n R3b Z W Q R3a H Y N R1 R4 R2 O (I) as described herein, along with stereoisomeric forms salts, hydrates, solvates, and salts thereof and pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.
• [EN] GENETICALLY-ENCODED BICYCLIC PEPTIDE LIBRARIES<br/>[FR] BIBLIOTHÈQUES DE PEPTIDE BICYCLIQUE GÉNÉTIQUEMENT CODÉ
  申请人：UNIV ALBERTA

  公开号：WO2020019072A1

  公开（公告）日：2020-01-30

  The invention relates to a bicyclic peptide complex comprising a peptide construct, said construct comprising (i) a polypeptide with free terminus (N or C); (ii) optionally, a nucleic acid encoding the polypeptide; (iii) a twofold-symmetric linker (TSL) compound attached to said polypeptide where the linker is attached to the terminus of polypeptide via a covalent bond and to at least two discrete side chains of the peptide. The invention also relates to libraries, and to methods for making complexes and to methods of screening using the same.