(2R:4S:6R:8R)-1,9-dihydroxy-4-hydroxymethyl-3,5,7-trioxa-nonane-2,4,6,8-tetracarboxylic acid | 84852-68-6

• 分子结构分类: 有机化合物
• 英文名称: (2R:4S:6R:8R)-1,9-dihydroxy-4-hydroxymethyl-3,5,7-trioxa-nonane-2,4,6,8-tetracarboxylic acid
• 英文别名: (2R:4S:6R:8R)-1,9-Dihydroxy-4-hydroxymethyl-3,5,7-trioxa-nonan-2,4,6,8-tetracarbonsaeure
• CAS: 84852-68-6
• 化学式: C₁₁H₁₆O₁₄
• 分子量: 372.24
• InChiKey: AEUZYLKFDHRVRI-HEEUFURKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.89
• 重原子数：
  25.0
• 可旋转键数：
  13.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  237.58
• 氢给体数：
  7.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (2R:4S:6R:8R)-1,9-dihydroxy-4-hydroxymethyl-3,5,7-trioxa-nonane-2,4,6,8-tetracarboxylic acid 、 硫酸 生成 D-甘油酸 、 二氧化碳 、 羟乙醛 、 乙醛酸
  参考文献：
  名称：

  Effects of First Myocardial Infarction on Left Ventricular Systolic and Diastolic Function with the Use of Mitral Annular Velocity Determined by Pulsed Wave Doppler Tissue Imaging

  摘要：

  This study was undertaken to assess the effect of a first myocardial Infarction CMI) on the systolic and diastolic velocity profiles of the mitral annulus determined by pulsed wave Doppler tissue imaging and thereby evaluate left ventricular (LV) function after MI. Seventy-eight patients with a first MI were examined before discharge. Peak systolic, peak early diastolic, and peak late diastolic velocities were recorded at 4 different sites on the mitral annulus corresponding to the septum, anterior, lateral and inferior sites of the left ventricle. In addition, the amplitude of mitral annular motion at the 4 above LV sites, the ejection fraction, and conventional Doppler diastolic parameters were recorded. Nineteen age-matched healthy subjects served as controls. Com pared with healthy subjects, the MI patients had a significantly reduced peak systolic velocity at the mitral annulus, especially at the infarction sites. A relatively good linear correlation was found between the ejection fraction and the mean systolic velocity from the 4 LV sites (r = 0.74, P <.001). The correlation was also good when the mean peak systolic mitral annular velocity was tested against the magnitude of the mean mitral annular motion (r = 0.77, P <.001). When the patients were divided into 2 different groups with respect to an ejection fraction greater than or equal to 0.50 or <0.50, a cutoff point of mean systolic mitral annular velocity of greater than or equal to 7.5 cm/s had a sensitivity of 79% and a specificity of 88% in predicting a preserved global LV systolic function. Similar to systolic velocities, the early diastolic velocity was also reduced, especially at the infarction sites. The peak mitral annular early diastolic velocity correlated well with both LV ejection fraction (r = 0.66, P <.001) and mean systolic mitral annular motion (r = 0.68, P <.001). However; no correlation existed between the early diastolic velocity and conventional diastolic Doppler parameters. The reduced peak systolic mitral annular velocity seems to be an expression of regionally reduced systolic function. The peak early diastolic velocity is also reduced, especially at the infarction sites, and reflects regional diastolic dysfunction. Thus, quantification of myocardial velocity by Doppler tissue imaging opens up a new possibility of assessing LV function along its long axis.

  DOI：

  10.1016/s0894-7317(00)70003-4
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 bromine oxide 作用下， 生成 (2R:4S:6R:8R)-1,9-dihydroxy-4-hydroxymethyl-3,5,7-trioxa-nonane-2,4,6,8-tetracarboxylic acid
  参考文献：
  名称：

  Lead Tetraacetate Oxidations in the Sugar Group. XI.¹ The Oxidation of Sucrose and Preparation of Glycerol and Glycol²

  摘要：

  DOI：

  10.1021/ja01161a073

文献信息

• Fleury; Courtois, Bulletin de la Societe Chimique de France, 1943, vol. <5> 10, p. 245
  作者：Fleury、Courtois

  DOI：——

  日期：——
• Fleury; Courtois, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1942, vol. 214, p. 366
  作者：Fleury、Courtois

  DOI：——

  日期：——