ethyl 2-bromo-4-(4-chlorobenzyl)-1,3-thiazole-5-carboxylate | 1206908-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-bromo-4-(4-chlorobenzyl)-1,3-thiazole-5-carboxylate
• 英文别名: Ethyl 2-bromo-4-(4-chlorobenzyl)thiazole-5-carboxylate；ethyl 2-bromo-4-[(4-chlorophenyl)methyl]-1,3-thiazole-5-carboxylate
• CAS: 1206908-25-9
• 化学式: C₁₃H₁₁BrClNO₂S
• 分子量: 360.659
• InChiKey: JMXGAQGDNCIOJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-bromo-4-(4-chlorobenzyl)-1,3-thiazole-5-carboxylate 、 potassium carbonate 、 吗啉 在 二氯甲烷 、 magnesium sulfate 、 crude product 、 silica gel 、 ethyl acetate n-hexane 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.5h， 以to give 3.44 g of the title compound as a white solid的产率得到Ethyl 4-(4-chlorobenzyl)-2-morpholinothiazole-5-carboxylate
  参考文献：
  名称：

  HETEROARYLS AND USES THEREOF

  摘要：

  本发明提供了式IA-i-a或IB-i-a及其子集的化合物:其中Z、HY、R1、R2、R3、G1、W、n和A及其子集如说明书所述。这些化合物是PI3K的抑制剂，因此可用于治疗增殖、炎症或心血管疾病。

  公开号：

  US20120172345A1

文献信息

• PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Sharma Lalima

  公开号：US20120108565A1

  公开（公告）日：2012-05-03

  The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Mvraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae ( E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.

  本发明提供了化学式(I)的DNA酶和/或拓扑异构酶IV抑制剂，可用作抗菌剂。本文披露的化合物可用于治疗或预防由革兰氏阳性、革兰氏阴性和厌氧细菌引起或加重的疾病，尤其对抗例如葡萄球菌、链球菌、肠球菌、流感嗜血杆菌、假单胞菌、阿氏变形杆菌、莫拉氏菌、沙雷菌、支原体、支原体、军团菌、分枝杆菌、幽门螺旋杆菌、梭菌、拟杆菌、克雷伯菌科（大肠杆菌、克雷伯氏菌、变形杆菌等）或其任意组合。还提供了制备本文披露的化合物的方法、含有本文披露的化合物的药物组合物以及治疗细菌感染的方法。
• Heteroaryls and uses thereof
  申请人：Freeze Brian S.

  公开号：US08796268B2

  公开（公告）日：2014-08-05

  This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

  本发明提供了公式IA-i-a或IB-i-a及其子集的化合物：其中Z，HY，R1，R2，R3，G1，W，n和A以及其子集如规范中所述。这些化合物是PI3K的抑制剂，因此可用于治疗增殖性，炎症性或心血管疾病。
• US8796268B2
  申请人：——

  公开号：US8796268B2

  公开（公告）日：2014-08-05
• US8796271B2
  申请人：——

  公开号：US8796271B2

  公开（公告）日：2014-08-05
• [EN] PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS D'ACIDE PYRROLE CARBOXYLIQUE EN TANT QU'AGENTS ANTIBACTÉRIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2010013222A1

  公开（公告）日：2010-02-04

  The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Mυraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp.,etc. ) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.