5-(5-methyl-1-((1-methyl-1H-indazol-4-yl)methyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole | 1570497-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(5-methyl-1-((1-methyl-1H-indazol-4-yl)methyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
• 英文别名: 5-[5-Methyl-1-[(1-methylindazol-4-yl)methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
• CAS: 1570497-79-8
• 化学式: C₂₁H₁₆F₃N₇O₂
• 分子量: 455.399
• InChiKey: AEJXBSDQPISITK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  96.7
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE
  申请人：Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center

  公开号：US20140066424A1

  公开（公告）日：2014-03-06

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

  本发明涉及化合物和方法，可用作HIF通路活性的抑制剂，用于治疗或预防癌症和其他缺氧介导的疾病。
• Heterocyclic modulators of HIF activity for treatment of disease
  申请人：Board of Regents, University of Texas System

  公开号：US10208059B2

  公开（公告）日：2019-02-19

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

  本发明涉及可作为 HIF 通路活性抑制剂用于治疗或预防癌症和其他缺氧介导的疾病的化合物和方法。
• Polymeric capsules
  申请人：The Procter & Gamble Company

  公开号：US11278857B2

  公开（公告）日：2022-03-22

  A population of capsules can include a plurality of capsules, the capsules can include a core including a benefit agent, and a polymeric shell surrounding the core. The population of capsules can have a delta fracture strength percentage of about 15% to about 230% and a shell thickness of about 20 nm to about 400 nm.

  胶囊群可以包括多个胶囊，胶囊可以包括一个包含益处剂的内核和一个围绕内核的聚合物外壳。胶囊群的 Delta 断裂强度百分比约为 15%至 230%，外壳厚度约为 20 纳米至 400 纳米。
• POLYMERIC CAPSULES
  申请人：The Procter & Gamble Company

  公开号：EP3955900A1

  公开（公告）日：2022-02-23
• METHODS OF MAKING POLYMERIC CAPSULES
  申请人：The Procter & Gamble Company

  公开号：EP3956053A1

  公开（公告）日：2022-02-23