2-(diethylamino)ethyl 4-(3-amino-4-cyano-6,6-dimethyl-6H-pyrano[3,4-c]pyridazin-2(8H)-yl)benzoate Trifluoroacetate | 406699-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(diethylamino)ethyl 4-(3-amino-4-cyano-6,6-dimethyl-6H-pyrano[3,4-c]pyridazin-2(8H)-yl)benzoate Trifluoroacetate
• 英文别名: 2-(diethylamino)ethyl 4-(3-amino-4-cyano-6,6-dimethyl-8H-pyrano[3,4-c]pyridazin-2-yl)benzoate;2,2,2-trifluoroacetic acid
• CAS: 406699-09-0
• 化学式: C₂HF₃O₂*C₂₃H₂₉N₅O₃
• 分子量: 537.539
• InChiKey: ROUOBSGZIVRULS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• Novel compounds
  申请人：——

  公开号：US20020115663A1

  公开（公告）日：2002-08-22

  The present invention is directed to novel pyridazine compounds of the formula I 1 as well as pharmaceutically and pharmacologically acceptable salts, and hydrates thereof; to a process for their preparation, their use and pharmaceutical compositions comprising said novel compounds. These novel compounds are useful in therapy, particularly for the treatment of type 2 diabetes mellitus.

  本发明涉及一种新型吡啶并嗪化合物，其化学式为I1，以及其药学和药理学上可接受的盐和水合物；以及它们的制备方法，用途和包含这些新型化合物的药物组合物。这些新型化合物在治疗中具有用途，特别是用于治疗2型糖尿病。
• [EN] ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYL OXAZOLIDINONES<br/>[FR] PHENYL-OXAZOLIDINONES SUBSTITUTEES HETEROBICYCLIQUES ANTIBACTERIENNES
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2001042242A1

  公开（公告）日：2001-06-14

  Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of formula (I): wherein Y is a radical of formulae (II) or (III) in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

  公式（I）中的二环杂环取代苯并噁唑啉化合物：其中Y是公式（II）或（III）的基团，其中取代基在描述中具有所示的含义。这些化合物可用作抗菌剂。
• ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYL OXAZOLIDINONES
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1206469A1

  公开（公告）日：2002-05-22
• [EN] NOVEL PYRIDAZINE COMPOUNDS FOR THE TREATMENT OF DIABETES<br/>[FR] NOUVEAUX COMPOSES DE PYRIDAZINE POUR LE TRAITEMENT DE DIABETES
  申请人：BIOVITRUM AB

  公开号：WO2002026743A1

  公开（公告）日：2002-04-04

  The present invention is directed to novel pyridazine compounds of the formula (I) as well as pharmaceutically and pharmaceutically acceptable salts, and hydrates thereof; to a process for their preparation, their use and pharmaceutical compositions comprising said novel compounds. These novel compounds are useful in therapy, particularly for the treatment of type 2 diabetes mellitus.