4-cyclohexylmethoxysalicylaldehyde | 1172635-15-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-cyclohexylmethoxysalicylaldehyde
• CAS: 1172635-15-2
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: HBAGOFJRQVBYLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.16
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  环己基甲基4-甲基苯磺酸盐 、 2,4-二羟基苯甲醛 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以17%的产率得到4-cyclohexylmethoxysalicylaldehyde
  参考文献：
  名称：

  Regioselective alkylation of hydroxysalicylaldehydes

  摘要：

  Schiff-base ligands are often used as backbone ligands for mono- and dinuclear complexes that serve as catalysts during aerobic oxidation reactions. However, their water Solubility is low and limits their applicability as catalysts to transform highly water-soluble biomolecules, such as carbohydrates or amino alcohols. A new method to regioselectively incorporate water solubility-promoting polyethylene glycol side chains into a frequently used aldehyde building block of Schiff-base ligands has been developed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.104