Nonioside B | 255904-23-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Nonioside B
• 英文别名: [(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] octanoate
• CAS: 255904-23-5
• 化学式: C₂₆H₄₆O₁₇
• 分子量: 630.6
• InChiKey: CTKLGODDPZHEHZ-BBENIMTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  43
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  275
• 氢给体数：
  10
• 氢受体数：
  17

文献信息

• EP1432429A4
  申请人：——

  公开号：EP1432429A4

  公开（公告）日：2005-09-21
• INHIBITION OF ANGIOGENESIS AND DESTRUCTION OF ANGIOGENIC VESSELS WITH EXTRACTS OF NONI JUICE MORINDA CITRIFOLIA
  申请人：Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

  公开号：EP1432429A1

  公开（公告）日：2004-06-30
• US8349374B2
  申请人：——

  公开号：US8349374B2

  公开（公告）日：2013-01-08
• [EN] INHIBITION OF ANGIOGENESIS AND DESTRUCTION OF ANGIOGENIC VESSELS WITH EXTRACTS OF NONI JUICE MORINDA CITRIFOLIA<br/>[FR] INHIBITION DE L'ANGIOGENESE ET DESTRUCTION DE VAISSEAUX ANGIOGENIQUES A L'AIDE D'EXTRAITS DE JUS DE NONI (MORINDA CITRIFOLIA)
  申请人：UNIV LOUISIANA STATE

  公开号：WO2003020296A1

  公开（公告）日：2003-03-13

  Noni juice and a protein-free, alcohol precipitate of Noni juice inhibited angiogenesis in in vitro human angiogenesis models. When growth medium contained Noni juice at least over the range from about 2.5% to about 33% (by volume), angiogenesis was blocked. Moreover, Noni juice and an ethanol precipitate were able to destroy a pre-existing angiogenic response as well as prevent the development of new vessels. Noni juice was effective in inhibiting the growth of angiogenic vessels from breast cancer explants. It will also be effective in treating cancers and non-cancerous diseases whose response includes an increase in angiogenesis, e.g., retinopathy of prematurity, neovascular glaucoma, diabetic retinopathy, and psoriasis. The primary antiangiogenic component is believed to be a carbohydrate with a molecular weight less than about 6000 Daltons. In an initial experiment, oral administration of Noni juice appeared to adversely affect the antioangiogenic component(s) in the juice.