chaetomugilin L | 1187848-02-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: chaetomugilin L
• 英文别名: (6aS,8S,9aS)-8-[(E)-but-2-en-2-yl]-5-chloro-8-methoxy-6a-methyl-3-[(E,3S)-3-methylpent-1-enyl]-9,9a-dihydrofuro[2,3-h]isochromen-6-one
• CAS: 1187848-02-7
• 化学式: C₂₃H₂₉ClO₄
• 分子量: 404.934
• InChiKey: KFQCGBJJOYTCQU-SISWDXRISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  chaetomugilin L 在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以84.2%的产率得到chaetomugilin J
  参考文献：
  名称：

  Chaetomugilins I–O, new potent cytotoxic metabolites from a marine-fish-derived Chaetomium species. Stereochemistry and biological activities

  摘要：

  Chaetomugilins I-O were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, as well as chemical transformations. These compounds exhibited significant growth inhibition of cultured P388, HL-60, L1210, and KB cell lines. In addition, chaetomugilin I showed selective cytotoxic activity against 39 human cancer cell lines. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.125

文献信息

• Chaetomugilins I–O, new potent cytotoxic metabolites from a marine-fish-derived Chaetomium species. Stereochemistry and biological activities
  作者：Yasuhide Muroga、Takeshi Yamada、Atsushi Numata、Reiko Tanaka

  DOI：10.1016/j.tet.2009.06.125

  日期：2009.9

  Chaetomugilins I-O were isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, as well as chemical transformations. These compounds exhibited significant growth inhibition of cultured P388, HL-60, L1210, and KB cell lines. In addition, chaetomugilin I showed selective cytotoxic activity against 39 human cancer cell lines. (C) 2009 Elsevier Ltd. All rights reserved.