2-imino-5,5-dimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide hydrochloride | 1202751-67-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-imino-5,5-dimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide hydrochloride
• 英文别名: 2-Imino-5,5-dimethyl-4-(2-phenylvinyl)-2,5-di-hydrofuran-3-carboxamide hydrochloride；2-imino-5,5-dimethyl-4-(2-phenylethenyl)furan-3-carboxamide;hydrochloride
• CAS: 1202751-67-4
• 化学式: C₁₅H₁₆N₂O₂*ClH
• 分子量: 292.765
• InChiKey: MLRSZLNEWSREKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  76.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-imino-5,5-dimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide hydrochloride 在 水 作用下， 反应 2.0h， 生成 5,5-dimethyl-2-oxo-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082
• 作为产物：
  描述：

  2-imino-5,5-dimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide 在 盐酸 作用下， 以 苯 为溶剂， 以98%的产率得到2-imino-5,5-dimethyl-4-(2-phenylvinyl)-2,5-dihydrofuran-3-carboxamide hydrochloride
  参考文献：
  名称：

  Synthesis of 2-imino-4-vinyl-2,5-dihydrofuran-3-carboxamides and some their chemical transformations

  摘要：

  2-Imino-2,5-dihydrofuran-3-carboxamides containing 2-phenyl- and 2-furylvinyl substituents in position 4 of the furan ring were synthesized by condensation of 2-imino-4-methyl-2,5-dihydrofuran-3-carboxamides with the corresponding aldehydes. Acid hydrolysis of 4-(2-arylvinyl)-2-imino-2,5-dihydrofuran-3-carboxamides gave 4-(2-arylvinyl)-2-oxo-2,5-dihydrofuran-3-carboxamides, and their condensation with malononitrile resulted in the formation of 2-dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428009070082