N-(6-{3-cyano-6-[(3-cyanopyridin-2-yl)oxy]-1-cyclobutyl-1H-indol-2-yl}pyridin-3-yl)propane-1-sulfonamide | 1248576-42-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(6-{3-cyano-6-[(3-cyanopyridin-2-yl)oxy]-1-cyclobutyl-1H-indol-2-yl}pyridin-3-yl)propane-1-sulfonamide
• 英文别名: N-[6-[3-cyano-6-(3-cyanopyridin-2-yl)oxy-1-cyclobutylindol-2-yl]pyridin-3-yl]propane-1-sulfonamide
• CAS: 1248576-42-2
• 化学式: C₂₇H₂₄N₆O₃S
• 分子量: 512.592
• InChiKey: OZJUZQNOAULEHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT<br/>[FR] DÉRIVÉS D'INDOLE ET MÉTHODES DE TRAITEMENT ANTIVIRAL
  申请人：SCHERING CORP

  公开号：WO2010117932A1

  公开（公告）日：2010-10-14

  The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

  本发明涉及化合物、形式和制药组合物，用于治疗病毒感染，或通过调节病毒复制来影响病毒活动。
• INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT
  申请人：Maccoss Malcolm

  公开号：US20120184574A1

  公开（公告）日：2012-07-19

  The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

  本发明涉及化合物及其形式和药物组成物，用于治疗病毒感染，或通过调节病毒复制来影响病毒活动。
• HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS
  申请人：PTC Therapeutics, Inc.

  公开号：EP2416765B1

  公开（公告）日：2016-03-30
• HCV Inhibitor and Therapeutic Agent Combinations
  申请人：Lahser Frederick C.

  公开号：US20120070412A1

  公开（公告）日：2012-03-22

  The present invention is directed to a combination product for treating or ameliorating hepatitis C virus (HCV) infection or disorders or symptoms associated therewith in a subject in need thereof comprising, a HCV inhibitor and one or more therapeutic agents selected from either or both a HCV protease inhibitor and one or more different therapeutic agents administered in combination in an effective amount to the subject.
• US8735414B2
  申请人：——

  公开号：US8735414B2

  公开（公告）日：2014-05-27