2,2-Dimethyl-5-methoxy-pentin-(3) | 55136-56-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Dimethyl-5-methoxy-pentin-(3)
• 英文别名: 1-methoxy-4,4-dimethyl-pent-2-yne；1-Methoxy-4,4-dimethylpent-2-yne
• CAS: 55136-56-6
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: NHWXHESYFHXHEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
  申请人：Saksena K. Anil

  公开号：US20070032433A1

  公开（公告）日：2007-02-08

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

  本发明揭示了具有HCV蛋白酶抑制活性的新化合物，以及制备这些化合物的方法。在另一种实施方式中，本发明揭示了包含这些化合物的药物组合物，以及使用它们治疗与HCV蛋白酶相关的疾病的方法。
• Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
  申请人：Akerman Michelle

  公开号：US20070142384A1

  公开（公告）日：2007-06-21

  The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L 1 -P-L 2 -M-X-L 3 -A wherein the definitions of the variables Q, L 1 , P, L 2 , M, X, L 3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

  本发明提供了一些化合物，例如用于调节受试者胰岛素水平的化合物，其具有以下一般式Q-L1-P-L2-M-X-L3-A，其中变量Q、L1、P、L2、M、X、L3和A的定义在此处提供。本发明还提供了该化合物的组合物和使用该化合物的方法，例如治疗II型糖尿病。
• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Ibrahim Prabha N.

  公开号：US20120245174A1

  公开（公告）日：2012-09-27

  Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf-1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.

  本文描述了化合物及其盐，制剂，共轭物，衍生物，形式和用途。在某些方面和实施例中，所述化合物或其盐，制剂，共轭物，衍生物和形式对BRaf和c-Raf-1蛋白激酶均具有活性，并且可能对A-Raf和B-Raf V600E蛋白激酶中的任一或两者也具有活性。还描述了使用它们治疗疾病和病症的方法，包括黑色素瘤，结肠直肠癌，甲状腺癌，卵巢癌和胆道癌。
• Oxadiazole Derivatives
  申请人：Quattropani Anna

  公开号：US20100240658A1

  公开（公告）日：2010-09-23

  The invention relates to compounds of formula I: wherein R 1 , R 2 , R a , R b , W, Q and S have the meanings given in claim 16 . The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.

  本发明涉及式I的化合物：其中R1、R2、Ra、Rb、W、Q和S的含义如权利要求16所述。该化合物可用于治疗自身免疫性疾病，如多发性硬化症。
• NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS
  申请人：Saksena Anil K.

  公开号：US20110117057A1

  公开（公告）日：2011-05-19

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

  本发明披露了具有HCV蛋白酶抑制活性的新化合物，以及制备这些化合物的方法。在另一种实施方式中，本发明披露了包含这些化合物的制药组合物，以及使用它们治疗与HCV蛋白酶相关的疾病的方法。