4-[4-(2-methyl-2H-benzotriazol-5-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-phenol | 676372-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[4-(2-methyl-2H-benzotriazol-5-yl)-5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-phenol
• 英文别名: 4-[4-(2-methylbenzotriazol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]phenol
• CAS: 676372-14-8
• 化学式: C₂₂H₁₈N₆O
• 分子量: 382.425
• InChiKey: JIUYJLUGKYGSEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  92.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS<br/>[FR] COMPOSES D'IMIDAZOLE UTILISES EN TANT QU'INHIBITEURS DU FACTEUR DE CROISSANCE TRANSFORMANT (TGF)
  申请人：PFIZER PROD INC

  公开号：WO2004026859A1

  公开（公告）日：2004-04-01

  Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ('TGF')-ß signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  本发明描述了新型咪唑化合物，包括其衍生物，它们的制备中间体，含有它们的药物组合物及其医药用途。本发明的化合物是转化生长因子（'TGF'-β）信号通路的强效抑制剂。它们可用于治疗各种TGF相关疾病状态，例如癌症和纤维化疾病。
• Novel imidazole compounds as transforming growth factor (TGF) inhibitors
  申请人：Pfizer Inc

  公开号：US20040106608A1

  公开（公告）日：2004-06-03

  Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-&bgr; signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  本发明涉及新型咪唑化合物及其衍生物，介于它们的制备中间体，含有它们的药物组合物，以及它们的药用。本发明的化合物是转化生长因子（“TGF”）-β信号通路的有效抑制剂。它们在治疗各种TGF相关疾病状态方面是有用的，包括癌症和纤维性疾病等。
• NOVEL IMIDAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
  申请人：Munchhof J. Michael

  公开号：US20070088037A1

  公开（公告）日：2007-04-19

  Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)- signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  本发明涉及新型咪唑化合物，包括其衍生物、制备中间体、含有它们的制药组合物以及它们的药用。本发明的化合物是转化生长因子（“TGF”）信号通路的有效抑制剂。它们在治疗各种与TGF相关的疾病状态中有用，包括癌症和纤维化疾病。
• US7153872B2
  申请人：——

  公开号：US7153872B2

  公开（公告）日：2006-12-26
• US7635702B2
  申请人：——

  公开号：US7635702B2

  公开（公告）日：2009-12-22