dimethyl 1-[4-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]phenyl]triazole-4,5-dicarboxylate | 1190202-96-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethyl 1-[4-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]phenyl]triazole-4,5-dicarboxylate
• CAS: 1190202-96-0
• 化学式: C₁₉H₂₃N₃O₁₀
• 分子量: 453.406
• InChiKey: JUXPYPPDPQJYEH-DXUMLVPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  183
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  4-azidobenzyl β-D-galactopyranoside 、 丁炔二酸二甲酯 以 甲醇 为溶剂， 反应 12.0h， 以86%的产率得到dimethyl 1-[4-[[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]phenyl]triazole-4,5-dicarboxylate
  参考文献：
  名称：

  Expanding the application scope of glycosidases using click chemistry

  摘要：

  Glycosidase-mediated glycosylation of alkynyl alcohols and azide-containing alcohols was followed by a click reaction, affording various types of triazole glycosides. The activities of triazole glycosides detected in Subsequent bioassays show that this procedure is a feasible approach to the development of anti-fungal drugs. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.11.044

文献信息

• Expanding the application scope of glycosidases using click chemistry
  作者：Wen-Ya Lu、Xing-Wen Sun、Chen Zhu、Jian-He Xu、Guo-Qiang Lin

  DOI：10.1016/j.tet.2009.11.044

  日期：2010.1

  Glycosidase-mediated glycosylation of alkynyl alcohols and azide-containing alcohols was followed by a click reaction, affording various types of triazole glycosides. The activities of triazole glycosides detected in Subsequent bioassays show that this procedure is a feasible approach to the development of anti-fungal drugs. (C) 2009 Elsevier Ltd. All rights reserved.