S-2-(3-Amino-propylamino)-propyl-dihydrogenphosphorothioat | 21735-91-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: S-2-(3-Amino-propylamino)-propyl-dihydrogenphosphorothioat
• 英文别名: 2-(3-Aminopropylamino)propylsulfanylphosphonic acid
• CAS: 21735-91-1
• 化学式: C₆H₁₇N₂O₃PS
• 分子量: 228.252
• InChiKey: HZVOOUWAFKEJBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N¹-(2-Bromo-1-methyl-ethyl)-propane-1,3-diamine; hydrobromide 生成 S-2-(3-Amino-propylamino)-propyl-dihydrogenphosphorothioat
  参考文献：
  名称：

  S-2-（ω-氨基烷基氨基）乙基二氢硫代磷酸酯和相关化合物作为潜在的抗辐射剂。

  摘要：

  DOI：

  10.1021/jm00302a010

文献信息

• LACTOFERRIN AS A RADIOPROTECTIVE AGENT
  申请人：Agennix Incorporated

  公开号：EP2049135A2

  公开（公告）日：2009-04-22
• [EN] LACTOFERRIN AS A RADIOPROTECTIVE AGENT<br/>[FR] LACTOFERRINE EN TANT QU'AGENT RADIOPROTECTEUR
  申请人：AGENNIX INC

  公开号：WO2007150049A2

  公开（公告）日：2007-12-27

  [EN] This present invention relates to the field of protecting against, or rectifying the effects of damaging ionizing irradiation. The method of treatment involves oral administration of a lactoferrin composition, alone or in combination with other treatments, both in combination with other radio-protective agents and/or the standard of care. Further, the method of treatment provides for a topical administration of lactoferrin to treat lesions caused by local damaging irradiation.
  [FR] La présente invention concerne un procédé de protection contre les effets nocifs d'un rayonnement ionisant ou de correction de ces effets. Le procédé de traitement, indépendant ou combiné à d'autres traitements, consiste à administrer oralement une composition de lactoferrine en association avec d'autres agents radioprotecteurs et/ou les normes de soin. Le procédé de traitement consiste également à administrer en application topique de la lactoferrine pour traiter des lésions provoquées par un rayonnement nocif local.
• [EN] MODULATORS OF TOUSLED KINASE IN CELLULAR PROCESSES<br/>[FR] MODULATEURS DE LA KINASE DE TYPE TOUSLED DANS DES PROCESSUS CELLULAIRES
  申请人：DE BENEDETTI ARRIGO

  公开号：WO2013119825A1

  公开（公告）日：2013-08-15

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides for methods and pharmaceutical agents to modulate the activity of Tousled-like kinase (TLK). The invention also provides for methods and pharmaceutical agents to inhibit the activity of Tousled-like kinase to provide increased sensitivity to irradiation (IR) and chemotherapeutic agents. The invention also provides for methods and pharmaceutical agents to increase the activity of Tousled-like kinase to provide increased protection against DNA damaging agents including to irradiation (IR) and chemotherapeutic agents.