盐酸双氢链霉素

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 盐酸双氢链霉素
• 英文名称: 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;hydron;chloride
• 化学式: C21H42ClN7O12
• 分子量: 620.0
• InChiKey: XGAKTAXPHNYSTK-RMIBZTJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.95
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  340
• 氢给体数：
  14
• 氢受体数：
  15

文献信息

• Urethral catheter capable of preventing urinary tract infection and process for producing the same
  申请人：UNITIKA LTD.

  公开号：EP0065884A1

  公开（公告）日：1982-12-01

  A urethral catheter composed of olefin polymer, diene polymer or silicone polymer as a base material wherein an antimicrobial substance being chemically bonded with the inside wall and/or the outside wall thereof, and a process for producing the same. This urethral catheter effectively prevents urinary tract infection for a long period of time.

  一种以烯烃聚合物、二烯聚合物或硅酮聚合物为基材，在其内壁和/或外壁化学键合抗菌物质的尿道导管及其生产工艺。 这种尿道导管可长期有效地防止尿路感染。
• Topical antibiotic composition for rapid wound healing
  申请人：VIROTEX CORPORATION

  公开号：EP0987019A1

  公开（公告）日：2000-03-22

  A composition and method for the treatment of wounds comprising a topical semisolid composition capable of providing a moist environment for a wound and reducing skin contraction by promoting increased water content in wounds becoming dry and reduced water content in wounds having excess exudate, wherein the topical semisolid comprises water and a polyhydric alcohol and two or more gelling agents. The topical semisolid composition is used in conjunction with antibiotic formulations.

  一种用于治疗伤口的组合物和方法，包括一种外用半固体组合物，该组合物能够为伤口提供湿润的环境，并通过促进变得干燥的伤口中水分含量的增加和具有过量渗出物的伤口中水分含量的减少来减少皮肤收缩，其中外用半固体组合物包括水和一种多元醇以及两种或两种以上的胶凝剂。外用半固体组合物与抗生素制剂一起使用。
• Method of treating benign prostatic hyperlasia with antibiotics
  申请人：Nymox Corporation

  公开号：US10835538B2

  公开（公告）日：2020-11-17

  Disclosed are methods of improving the symptoms of mammals suffering from BPH using compositions containing one or more antibiotics. The method includes, but is not limited to, administering at least one antibiotic in one or more courses of treatment by one or more administration routes selected from intramuscularly, orally, intravenously, intrathecally, intratumorally, intranasally, topically, and transdermally, either alone or with a carrier to a mammal in need thereof.

  本发明公开了使用含有一种或多种抗生素的组合物改善患有前列腺增生症的哺乳动物症状的方法。该方法包括，但不限于，在一个或多个疗程中，通过选自肌肉注射、口服、静脉注射、鞘内注射、瘤内注射、鼻内注射、局部注射和透皮注射的一种或多种给药途径，单独或与载体一起给需要的哺乳动物施用至少一种抗生素。
• METHODS AND COMPOSITIONS FOR TOPICAL TREATMENT OF DAMAGED TISSUE USING REACTIVE OXYGEN METABOLITE PRODUCTION OR RELEASE INHIBITORS
  申请人：Maxim Pharmaceuticals, Inc.

  公开号：EP1143969A1

  公开（公告）日：2001-10-17
• METHOD OF TREATING BENIGN PROSTATIC HYPERLASIA WITH ANTIBIOTICS
  申请人：Nymox Corporation

  公开号：EP3743089A1

  公开（公告）日：2020-12-02