(2S,2'S,2''S,2'''S)-N,N',N'',N'''-((5S,5'S)-(((S)-6-(dodecylamino)-6-oxohexane-1,5-diyl)bis(azanediyl))bis(6-oxohexane-6,1,5-triyl))tetrakis(2,6-diaminohexanamide) | 1324842-06-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,2'S,2''S,2'''S)-N,N',N'',N'''-((5S,5'S)-(((S)-6-(dodecylamino)-6-oxohexane-1,5-diyl)bis(azanediyl))bis(6-oxohexane-6,1,5-triyl))tetrakis(2,6-diaminohexanamide)
• CAS: 1324842-06-9
• 化学式: C₅₄H₁₁₁N₁₅O₇
• 分子量: 1082.57
• InChiKey: XLCKNPQQUPTBQD-DRODSASKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  76.0
• 可旋转键数：
  52.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  411.86
• 氢给体数：
  15.0
• 氢受体数：
  15.0

反应信息

• 作为产物：
  描述：

  1,1,1-trifluoro-4-(4-fluoro-2-methoxyphenyl)-4-methylpentan-2-ol 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 、 N,N'-双芴甲氧羰基-L-赖氨酸 在 N,N'-二异丙基碳二亚胺 作用下， 以 N-甲基吡咯烷酮 、 二氯甲烷 为溶剂， 反应 16.25h， 以31%的产率得到(2S,2'S,2''S,2'''S)-N,N',N'',N'''-((5S,5'S)-(((S)-6-(dodecylamino)-6-oxohexane-1,5-diyl)bis(azanediyl))bis(6-oxohexane-6,1,5-triyl))tetrakis(2,6-diaminohexanamide)
  参考文献：
  名称：

  Solid-phase synthesis of polyfunctional polylysine dendrons using aldehyde linkers

  摘要：

  A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal 'tail groups' such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.04.127