(E)-N-benzyl-N-(but-2-en-1-yl)-2,2-dichlorobutanamide | 1215092-41-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-N-benzyl-N-(but-2-en-1-yl)-2,2-dichlorobutanamide
• CAS: 1215092-41-3
• 化学式: C₁₅H₁₉Cl₂NO
• 分子量: 300.228
• InChiKey: QFCRNOOWFPQEPY-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  19.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  2,2-dichlorobutanoyl chloride 、 N-benzyl-N-crotylamine 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 、 (E)-N-benzyl-N-(but-2-en-1-yl)-2,2-dichlorobutanamide
  参考文献：
  名称：

  Functional rearrangement of 3-Cl or 3,3-diCl-γ-lactams bearing a secondary 1-chloroalkyl substituent at C-4

  摘要：

  The study of the reaction with MeONa/MeOH of chlorinated gamma-lactams. prepared from the atom transfer radical cyclization of N-allyl-alpha-perchloroamides, has been extended to the case of substiates carrying an exo halogen atom on a branched carbon Only with secondary exo C-Cl groups, that are not located on a fused ring, does the functional rearrangement follow the typical transformation route, Which With trichloro-lactams can proceed further to give 4-alkylidene derivatives From a practical point of view, the outcome of the reaction with di- or trichloio N-cinnamylamides is synthetically valuable, affording the 5-methoxy-IH-pyrrol-2(5H)-one or 3-benzylidenepyrrlidine-2.5-dione. respectively. in good to excellent yield (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.11.111