[2-(2-methoxyphenyl)ethyl]trimethylsilane | 1436413-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [2-(2-methoxyphenyl)ethyl]trimethylsilane
• 英文别名: 2-(2-Methoxyphenyl)ethyl-trimethylsilane
• CAS: 1436413-60-3
• 化学式: C₁₂H₂₀OSi
• 分子量: 208.376
• InChiKey: KJVRISVGBLOASL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(三甲基甲硅烷基乙炔基)苯甲醚 在 (bis(mesityl-benzimidazol-2-ylidene)phenyl)Co(N₂)(PPh₃) 、 氢气 作用下， 以 四氢呋喃 为溶剂， 30.0 ℃ 、405.33 kPa 条件下， 反应 17.0h， 以77%的产率得到(E)-三甲基<2-(2-甲氧基苯基)乙烯基>硅烷
  参考文献：
  名称：

  Alkyne Semihydrogenation with a Well-Defined Nonclassical Co–H₂ Catalyst: A H₂ Spin on Isomerization and E-Selectivity

  摘要：

  The reactivity of a co(I)-H-2 complex was extended toward the semihydrogenation of internal alkynes. Under ambient temperatures and moderate pressures of H-2, a broad scope of alkynes were semihydrogenated using a Co-I-N-2 precatalyst, resulting in the formation of trans-alkene products. Furthermore, mechanistic studies using H-1, H-2, and parahydrogen induced polarization (PHIP) transfer NMR spectroscopy revealed cis -hydrogenation of the alkyne occurs first. The Co-mediated alkene isomerization afforded the E-selective products from a broad group of alkynes with good yields and E/Z selectivity.

  DOI：

  10.1021/jacs.6b08128

文献信息

• Regioselective CH Alkylation of Anisoles with Olefins Catalyzed by Cationic Half-Sandwich Rare Earth Alkyl Complexes
  作者：Juzo Oyamada、Zhaomin Hou

  DOI：10.1002/anie.201206233

  日期：2012.12.14

  A half sandwich helping: Cationic rare‐earth alkyl species generated from half‐sandwich rare‐earth dialkyl complexes and [Ph3C][B(C6F5)4] can serve as unique catalysts for the CH regioselective alkylation of anisoles with alkenes. The reaction affords either ortho‐monoalkylated derivatives or products substituted at the benzylic position, depending on the substrate chosen.

  半三明治有助于：由半三明治稀土二烷基配合物和[Ph 3 C] [B（C 6 F 5）4 ]生成的阳离子稀土烷基可作为CH区域选择性烷基化的独特催化剂烯烃的芳烃。根据所选择的底物，反应可提供邻-单烷基化的衍生物或在苄基位置被取代的产物。