垂盆钞草甙(治肝炎药),垂盆草甙 | 71933-54-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 垂盆钞草甙(治肝炎药),垂盆草甙
• 中文别名: 垂盆草甙
• 英文名称: Sarmentosin
• 英文别名: (E)-2-(hydroxymethyl)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybut-2-enenitrile
• CAS: 71933-54-5
• 化学式: C₁₁H₁₇NO₇
• 分子量: 275.258
• InChiKey: FWAYDNJCBHNWQD-JBWLPIRVSA-N

物化性质

• 沸点：
  621.9±55.0 °C(Predicted)
• 密度：
  1.51

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  143
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (E)-1-(tert-butyldiphenylsilyloxy)-2-cyano-4-β-D-tetraacetylglucopyranosyloxy-2-butene 在 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 5.5h， 生成 垂盆钞草甙(治肝炎药),垂盆草甙
  参考文献：
  名称：

  A Facile and Convergent Synthesis of Sarmentosin

  摘要：

  A concise synthesis of sarmentosin (1) starting from butane-1,2,4-triol-1,2-acetonide is described. This convergent route can also be employed for the preparation of sarmentosin analogues for structure-activity relationship studies.

  DOI：

  10.1081/scc-120023993

文献信息

• ALKALOID COMPOSITIONS FROM RIBES SPECIES TO TREAT CONDITIONS ASSOSIATED WITH MITOCHONDRIAL FUNCTION OR INHIBITION OF PDE4, PDE5 AND IKK-BETA
  申请人：Asiros A/S

  公开号：EP2859007A1

  公开（公告）日：2015-04-15
• ALKALOID COMPOSITIONS FROM RIBES SPECIES TO TREAT CONDITIONS ASSOCIATED WITH MITOCHONDRIAL FUNCTION OR INHIBITION OF PDE4, PDE5 AND IKK-BETA
  申请人：Olle Svenssons Partiaffär AB

  公开号：EP2859007B1

  公开（公告）日：2019-04-17
• Bioactive Alkaloid Compositions and Their Medical Uses
  申请人：Asiros A/S

  公开号：US20160184338A1

  公开（公告）日：2016-06-30

  The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum ; methods of manufacturing such bioactive Ribes alkaloid fractions and their use for the inhibition of IKK-β, PDE4 and/or PDE5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non-therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or IKK-β, PDE4 and/or PDE5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of Ribes comprising such alkaloids; compositions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices.
• US9023816B2
  申请人：——

  公开号：US9023816B2

  公开（公告）日：2015-05-05
• [EN] ALKALOID COMPOSITIONS FROM RIBES SPECIES TO TREAT CONDITIONS ASSOSIATED WITH MITOCHONDRIAL FUNCTION OR INHIBITION OF PDE4, PDE5 AND IKK-BETA<br/>[FR] COMPOSITIONS ALCALOÏDES PROVENANT D'ESPÈCES DU GENRE RIBES DESTINÉES À TRAITER DES ÉTATS PATHOLOGIQUES ASSOCIÉS À UNE FONCTION MITOCHONDRIALE OU À L'INHIBITION DE PDE4, DE PDE5 ET D'IKK-BETA
  申请人：ASIROS AS

  公开号：WO2015007291A1

  公开（公告）日：2015-01-22

  The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum; methods of manufacturing such bioactive Ribes alkaloid fractions and their use for the inhibition of IKK-β, PDE4 and/or PDE5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non- therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or IKK-β, PDE4 and/or PDE5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of Ribes comprising such alkaloids; compositions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices.