1-[3-Chloro-4,5-bis[(4-methoxyphenyl)methoxy]phenyl]ethanone | 1609071-32-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[3-Chloro-4,5-bis[(4-methoxyphenyl)methoxy]phenyl]ethanone
• CAS: 1609071-32-0
• 化学式: C₂₄H₂₃ClO₅
• 分子量: 426.897
• InChiKey: VHKVLCWOJXFCHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 2 SUBSTITUTED CEPHEM COMPOUNDS<br/>[FR] COMPOSÉS DE CÉPHEM SUBSTITUÉS EN POSITION 2
  申请人：GLAXO GROUP LTD

  公开号：WO2014068388A1

  公开（公告）日：2014-05-08

  The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

  本发明的化学式（I）的化合物与2-取代头孢菌素类化合物相关，具有广泛的抗微生物谱，特别对产β-内酰胺酶的革兰氏阴性细菌表现出强效的抗微生物活性，并且包含这些化合物的药物组合物。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• CEPHEM COMPOUND HAVING CATECHOL GROUP
  申请人：Hisakawa Shinya

  公开号：US20130102583A1

  公开（公告）日：2013-04-25

  A compound of the formula: wherein X is —N═, —CH═, or the like; W is —CH 2 — or the like; U is —S— or the like; R 1 and R 2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; R 3 is hydrogen or the like; each R 4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; Q is a single bond, or the like; G is —C(═O)—, or the like; D is a single bond, —NH—, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.
• 2 SUBSTITUTED CEPHEM COMPOUNDS
  申请人：Glaxo Group Limited

  公开号：US20170281532A1

  公开（公告）日：2017-10-05

  The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.
• US9145425B2
  申请人：——

  公开号：US9145425B2

  公开（公告）日：2015-09-29