(Z)-1-Oxazol-2-yl-octadec-9-en-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-1-Oxazol-2-yl-octadec-9-en-1-one
• 英文别名: (Z)-1-(oxazol-2-yl)octadec-9-en-1-one；(Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one
• 化学式: C₂₁H₃₅NO₂
• 分子量: 333.514
• InChiKey: WWYUNXGFLPTVRR-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  恶唑 、 油酰氯 生成 (Z)-1-Oxazol-2-yl-octadec-9-en-1-one
  参考文献：
  名称：

  α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution

  摘要：

  Two sets of novel analogues of the recently disclosed alpha -keto heterocycle inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for regulation of endogenous oleamide and anandamide, were synthesized and evaluated in order to clarify a role of the electrophilic carbonyl group and structural features important for their activity. Both the electrophilic carbonyl and the degree of alpha -substitution markedly affect inhibitor potency. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00211-6

文献信息

• INHIBITORS OF FATTY ACID AMIDE HYDROLASE
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：EP1549624B1

  公开（公告）日：2009-05-13
• US7560570B2
  申请人：——

  公开号：US7560570B2

  公开（公告）日：2009-07-14
• α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution
  作者：Dale L Boger、Hiroshi Miyauchi、Michael P Hedrick

  DOI：10.1016/s0960-894x(01)00211-6

  日期：2001.6

  Two sets of novel analogues of the recently disclosed alpha -keto heterocycle inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for regulation of endogenous oleamide and anandamide, were synthesized and evaluated in order to clarify a role of the electrophilic carbonyl group and structural features important for their activity. Both the electrophilic carbonyl and the degree of alpha -substitution markedly affect inhibitor potency. (C) 2001 Elsevier Science Ltd. All rights reserved.