N-(4-(4-(1H-pyrazol-1-yl)phenyl)-2-(4-fluorophenyl)thiazol-5-yl)-N-(4-chlorophenethyl)furan-2-carboxamide | 1187843-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(4-(1H-pyrazol-1-yl)phenyl)-2-(4-fluorophenyl)thiazol-5-yl)-N-(4-chlorophenethyl)furan-2-carboxamide
• 英文别名: N-[2-(4-chlorophenyl)ethyl]-N-[2-(4-fluorophenyl)-4-(4-pyrazol-1-ylphenyl)-1,3-thiazol-5-yl]furan-2-carboxamide
• CAS: 1187843-75-9
• 化学式: C₃₁H₂₂ClFN₄O₂S
• 分子量: 569.059
• InChiKey: GHPBQDXARHQIJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  92.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  呋喃甲酰氯 、 4-(4-(1H-pyrazol-1-yl)phenyl)-N-(4-chlorophenethyl)-2-(4-fluorophenyl)thiazol-5-amine 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以247 mg的产率得到N-(4-(4-(1H-pyrazol-1-yl)phenyl)-2-(4-fluorophenyl)thiazol-5-yl)-N-(4-chlorophenethyl)furan-2-carboxamide
  参考文献：
  名称：

  Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives

  摘要：

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.

  DOI：

  10.1021/jo9014529