[10-Methyl-2-[8-methyl-4-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-9-prop-2-enoxy-8-(prop-2-enoxymethyl)nonyl]-6-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-11-prop-2-enoxy-10-(prop-2-enoxymethyl)undecoxy]methylbenzene | 1424713-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [10-Methyl-2-[8-methyl-4-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-9-prop-2-enoxy-8-(prop-2-enoxymethyl)nonyl]-6-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-11-prop-2-enoxy-10-(prop-2-enoxymethyl)undecoxy]methylbenzene
• CAS: 1424713-02-9
• 化学式: C₆₉H₁₁₆O₉
• 分子量: 1089.67
• InChiKey: VBDZSGYIESWLFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.6
• 重原子数：
  78
• 可旋转键数：
  60
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [10-Methyl-2-[8-methyl-4-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-9-prop-2-enoxy-8-(prop-2-enoxymethyl)nonyl]-6-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-11-prop-2-enoxy-10-(prop-2-enoxymethyl)undecoxy]methylbenzene 在 四氧化锇 、 水 、 N-甲基吗啉氧化物 作用下， 以 丙酮 、 叔丁醇 为溶剂， 反应 24.0h， 以64%的产率得到3-[19-(2,3-Dihydroxypropoxy)-6,14-bis[5-(2,3-dihydroxypropoxy)-4-(2,3-dihydroxypropoxymethyl)-4-methylpentyl]-2,18-bis(2,3-dihydroxypropoxymethyl)-2,18-dimethyl-10-(phenylmethoxymethyl)nonadecoxy]propane-1,2-diol
  参考文献：
  名称：

  Versatile Synthesis of Amphiphilic Oligo(Aliphatic-Glycerol) Layer-Block Dendrons with Different Hydrophilic-Lipophilic Balance Values

  摘要：

  A series of amphiphilic oligo(glycerol-aliphatic) layer-blocked dendrons with different hydrophilic-lipophilic balance values (3.5-15.0) was prepared for use in controlled drug delivery and self-assembly studies. The synthetic strategies involved first a convergent growth of the inner hydrophobic sector followed by a divergent growth of the outer hydrophilic sector.

  DOI：

  10.1055/s-0032-1317929
• 作为产物：
  描述：

  Methyl 9-(2,2,5-trimethyl-1,3-dioxan-5-yl)-6-[3-(2,2,5-trimethyl-1,3-dioxan-5-yl)propyl]-2-[7-(2,2,5-trimethyl-1,3-dioxan-5-yl)-4-[3-(2,2,5-trimethyl-1,3-dioxan-5-yl)propyl]heptyl]nonanoate 在 lithium aluminium tetrahydride 、 水 、 四丁基碘化铵 、 sodium hydride 、 溶剂黄146 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 、 甲苯 、 mineral oil 为溶剂， 反应 110.0h， 生成 [10-Methyl-2-[8-methyl-4-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-9-prop-2-enoxy-8-(prop-2-enoxymethyl)nonyl]-6-[4-methyl-5-prop-2-enoxy-4-(prop-2-enoxymethyl)pentyl]-11-prop-2-enoxy-10-(prop-2-enoxymethyl)undecoxy]methylbenzene
  参考文献：
  名称：

  Versatile Synthesis of Amphiphilic Oligo(Aliphatic-Glycerol) Layer-Block Dendrons with Different Hydrophilic-Lipophilic Balance Values

  摘要：

  A series of amphiphilic oligo(glycerol-aliphatic) layer-blocked dendrons with different hydrophilic-lipophilic balance values (3.5-15.0) was prepared for use in controlled drug delivery and self-assembly studies. The synthetic strategies involved first a convergent growth of the inner hydrophobic sector followed by a divergent growth of the outer hydrophilic sector.

  DOI：

  10.1055/s-0032-1317929