t-Butyl-(3,3-diethoxypropyl)-amin | 45123-57-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: t-Butyl-(3,3-diethoxypropyl)-amin
• 英文别名: N-(3,3-diethoxypropyl)-2-methylpropan-2-amine
• CAS: 45123-57-7
• 化学式: C₁₁H₂₅NO₂
• 分子量: 203.325
• InChiKey: TVRNJBITZUNTGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙醇 、 1-tert-Butyl-2-cyano-azetidin 在 silver nitrate 作用下， 生成 t-Butyl-(3,3-diethoxypropyl)-amin
  参考文献：
  名称：

  Reaction of 1-t-Butyl-2-cyanoazetidine with Silver Nitrate or Silver Perchlorate

  摘要：

  DOI：

  10.1246/bcsj.43.3281

文献信息

• Anilino-pyrimidine phenyl and benzothiophene analogs
  申请人：Hu Yongbo

  公开号：US20070244140A1

  公开（公告）日：2007-10-18

  The present invention relates to compounds of formula III: wherein R 2 , R 3 , R 5 and R 6 are as defined herein.

  本发明涉及以下式III的化合物： 其中R2、R3、R5和R6如本文所定义。
• CRYSTALLINE POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS D-GLUCORONATE SALTS
  申请人：Mirmehrabi Mahmoud

  公开号：US20080262010A1

  公开（公告）日：2008-10-23

  The present invention relates to methods for preparing one or more crystalline polymorphs of a compound of formula I: and structurally related compounds. The present invention is also directed to methods for converting one polymorph to other different polymorphs of formula I and structurally related compounds.

  本发明涉及制备化合物I的一个或多个结晶多型的方法，以及与结构相关的化合物。本发明还涉及将一个多型转化为化合物I的其他不同多型的方法，以及与结构相关的化合物。
• CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS PHARMACEUTICALLY ACCEPTABLE SALTS
  申请人：Mirmehrabi Mahmoud

  公开号：US20080275073A1

  公开（公告）日：2008-11-06

  The present invention relates to one or more crystalline forms and polymorphs of compounds of formula I: in the form of pharmaceutically acceptable salts. The present invention is directed to crystalline polymorphs and forms of specific anilino-pyrimidine benzenesulfonamide compounds of formula I as pharmaceutically acceptable salts.

  本发明涉及公式I化合物的一个或多个结晶形式和多型体，以药用盐的形式。本发明涉及公式I特定苯磺酰胺类芳基吡啶化合物的结晶多型体和形式，作为药用盐。
• CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS SUCCINATE SALTS
  申请人：Mirmehrabi Mahmoud

  公开号：US20080262008A1

  公开（公告）日：2008-10-23

  The present invention relates to methods for preparing and manufacturing a crystalline form or polymorph of a compound of formula I: in the form of pharmaceutically acceptable salts and polymorphs thereof. The present invention is directed to methods for preparing and manufacturing crystalline polymorphs or forms of specific anilino-pyrimidine benzenesulfonamide compounds. Methods for converting one crystalline form or polymorph of compounds of formula I as their pharmaceutically acceptable salt polymorph to other different crystalline polymorphs of compounds of formula I as their corresponding pharmaceutically acceptable salt are also disclosed.

  本发明涉及制备和制造化合物I的结晶形式或多型的方法：以药学上可接受的盐和多型的形式。本发明涉及制备和制造特定苯磺酰胺基吡啶类化合物的结晶多型或形式的方法。还揭示了将化合物I的一种结晶形式或多型转化为其他不同的化合物I的结晶多型，作为相应的药学上可接受的盐的方法。
• CRYSTALLINE POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS ACETATE SALTS
  申请人：Mirmehrabi Mahmoud

  公开号：US20080262009A1

  公开（公告）日：2008-10-23

  The present invention relates to methods for preparing one or more crystalline forms and polymorphs of a compound of formula I: and structurally related compounds. The present invention is also directed to methods for converting one polymorph to other different polymorphs of formula I and structurally related compounds.

  本发明涉及制备一种或多种化合物I的晶体形式和多晶形式的方法，以及与化合物I结构相关的化合物。本发明还涉及将一种多晶形式转化为化合物I和结构相关化合物的其他不同多晶形式的方法。