N-acetyl-4-[2-(4-fluorophenyl)-6-(trifluoromethyt)pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide | 267235-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-acetyl-4-[2-(4-fluorophenyl)-6-(trifluoromethyt)pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide
• 英文别名: N-acetyl-4-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide；N-[4-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]phenyl]sulfonylacetamide
• CAS: 267235-24-5
• 化学式: C₂₂H₁₅F₄N₃O₃S
• 分子量: 477.439
• InChiKey: GPQXUWFOWHFIMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-[2-(4-fluoro-phenyl)-6-trifluoromethyl-pyrazolo[1,5-a]pyridin-3-yl]-benzenesulfonamide 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以31%的产率得到N-acetyl-4-[2-(4-fluorophenyl)-6-(trifluoromethyt)pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide
  参考文献：
  名称：

  PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS

  摘要：

  公开号：

  EP1127058B1

文献信息

• Pyrazolopyridine derivatives as selective cox-2 inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US07223772B1

  公开（公告）日：2007-05-29

  The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from the group consisting of H, halogen, C1-6alkyl, C1-6alkoxy, and C1-6alkoxy substituted by one or more fluorine atoms; R2 is selected from the group consisting of H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, and C1-6alkoxy substituted by one or more fluorine atoms; and R3 is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.

  本发明提供了公式（I）的化合物及其药学上可接受的衍生物，其中：R0和R1独立地选自H，卤素，C1-6烷基，C1-6烷氧基和一个或多个氟原子取代的C1-6烷氧基；R2选自H，C1-6烷基，一个或多个氟原子取代的C1-6烷基，C1-6烷氧基，C1-6羟基烷基，SC1-6烷基，C（O）H，C（O）C1-6烷基，C1-6烷基磺酰基和一个或多个氟原子取代的C1-6烷氧基；R3为C1-6烷基或NH2。公式（I）的化合物是COX-2的有效和选择性抑制剂，并可用于治疗各种疾病的疼痛，发热和炎症。
• US7223772B1
  申请人：——

  公开号：US7223772B1

  公开（公告）日：2007-05-29
• [EN] PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS<br/>[FR] DERIVES DE PYRAZOLOPYRIDINE UTILISES COMME INHIBITEURS SELECTIFS DE COX-2
  申请人：GLAXO GROUP LTD

  公开号：WO2000026216A1

  公开（公告）日：2000-05-11

  The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which : R?0 and R1¿ are independently selected from H, halogen, C¿1-6?alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R?2¿ is H, C¿1-6?alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms; and R?3¿ is C¿1-6?alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.