2-(6-bromo-1,3-benzodioxol-5-yl)-N-[2-(4-phenylmethoxyphenyl)ethyl]acetamide | 1592683-34-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(6-bromo-1,3-benzodioxol-5-yl)-N-[2-(4-phenylmethoxyphenyl)ethyl]acetamide
• CAS: 1592683-34-5
• 化学式: C₂₄H₂₂BrNO₄
• 分子量: 468.347
• InChiKey: OIQYPBYIMJXIRZ-UHFFFAOYSA-N

物化性质

• 沸点：
  661.3±55.0 °C(predicted)
• 密度：
  1.402±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(6-bromo-1,3-benzodioxol-5-yl)-N-[2-(4-phenylmethoxyphenyl)ethyl]acetamide 在 吡啶 、 sodium tetrahydroborate 、 三氟甲磺酸 、 di-tert-butyl(methyl)phosphonium tetrafluoroborate salt 、 palladium 10% on activated carbon 、 氢气 、 palladium diacetate 、 potassium carbonate 、 N,N-二乙基苯胺 、 potassium iodide 作用下， 以 甲醇 、 二氯甲烷 、 二甲基亚砜 、 乙腈 为溶剂， 反应 28.95h， 生成
  参考文献：
  名称：

  Evaluation of structural effects on 5-HT2A receptor antagonism by aporphines: Identification of a new aporphine with 5-HT2A antagonist activity

  摘要：

  A set of aporphine analogs related to nantenine was evaluated for antagonist activity at 5-HT2A and alpha(1A) adrenergic receptors.With regards to 5-HT2A receptor antagonism, a C2 allyl group is detrimental to activity. The chiral center of nantenine is not important for 5-HT2A antagonist activity, however the N6 nitrogen atom is a critical feature for 5-HT2A antagonism.Compound 12b was the most potent 5-HT2A aporphine antagonist identified in this study and has similar potency to previously identified aporphine antagonists 2 and 3. The ring A and N6 modifications examined were detrimental to alpha(1A) antagonism. A slight eutomeric preference for the R enantiomer of nantenine was observed in relation to alpha(1A) antagonism. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.066
• 作为产物：
  描述：

  (6-溴-苯并1,3二氧代-5-基)-乙酸 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 2-(6-bromo-1,3-benzodioxol-5-yl)-N-[2-(4-phenylmethoxyphenyl)ethyl]acetamide
  参考文献：
  名称：

  Evaluation of structural effects on 5-HT2A receptor antagonism by aporphines: Identification of a new aporphine with 5-HT2A antagonist activity

  摘要：

  A set of aporphine analogs related to nantenine was evaluated for antagonist activity at 5-HT2A and alpha(1A) adrenergic receptors.With regards to 5-HT2A receptor antagonism, a C2 allyl group is detrimental to activity. The chiral center of nantenine is not important for 5-HT2A antagonist activity, however the N6 nitrogen atom is a critical feature for 5-HT2A antagonism.Compound 12b was the most potent 5-HT2A aporphine antagonist identified in this study and has similar potency to previously identified aporphine antagonists 2 and 3. The ring A and N6 modifications examined were detrimental to alpha(1A) antagonism. A slight eutomeric preference for the R enantiomer of nantenine was observed in relation to alpha(1A) antagonism. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.066