3-azidopropyl 6-O-acetyl-2,4-di-O-benzoyl-3-O-(2-naphthylmethyl)-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranoside | 1190749-41-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-azidopropyl 6-O-acetyl-2,4-di-O-benzoyl-3-O-(2-naphthylmethyl)-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranoside
• CAS: 1190749-41-7
• 化学式: C₆₃H₅₇N₃O₁₇
• 分子量: 1128.16
• InChiKey: IEJXUQVAKYWFRZ-HXMGEVFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  83.0
• 可旋转键数：
  23.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  252.71
• 氢给体数：
  0.0
• 氢受体数：
  18.0

反应信息

• 作为反应物：
  描述：

  3-azidopropyl 6-O-acetyl-2,4-di-O-benzoyl-3-O-(2-naphthylmethyl)-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranoside 在 水 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 24.0h， 以62%的产率得到3-azidopropyl 6-O-acetyl-2,4-di-O-benzoyl-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of 3,6-branched arabinogalactan-type tetra- and hexasaccharides for characterization of monoclonal antibodies

  摘要：

  Synthesis of tetra- and hexasaccharides built up from a beta-(1 -> 6)-linked galactopyranosyl backbone with arabinofuranosyl side chains at position 3 and with a 3-aminopropyl spacer related to arabinogalactans is described. These oligosaccharides were prepared for investigation of monoclonal antibodies raised against arabinogalactan proteins (AGPs) from pressed juice of Echinacea purpurea. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.04.025
• 作为产物：
  描述：

  3-azidopropyl 2,3,4-tri-O-benzoyl-β-D-galactopyranoside 、 phenyl 6-O-acetyl-2,4-di-O-benzoyl-3-O-(2-naphthylmethyl)-1-thio-β-D-galactopyranoside 在 N-碘代丁二酰亚胺 、 silver trifluoromethanesulfonate 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 以76%的产率得到3-azidopropyl 6-O-acetyl-2,4-di-O-benzoyl-3-O-(2-naphthylmethyl)-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of 3,6-branched arabinogalactan-type tetra- and hexasaccharides for characterization of monoclonal antibodies

  摘要：

  Synthesis of tetra- and hexasaccharides built up from a beta-(1 -> 6)-linked galactopyranosyl backbone with arabinofuranosyl side chains at position 3 and with a 3-aminopropyl spacer related to arabinogalactans is described. These oligosaccharides were prepared for investigation of monoclonal antibodies raised against arabinogalactan proteins (AGPs) from pressed juice of Echinacea purpurea. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.04.025