9-(3'-Fluoro-3'-deoxyxylofuranosyl)adenine | 20535-16-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 9-(3'-Fluoro-3'-deoxyxylofuranosyl)adenine
• 英文别名: (2R,3S,4S,5R)-5-(6-aminopurin-9-yl)-3-fluoro-2-(hydroxymethyl)oxolane-3,4-diol
• CAS: 20535-16-4
• 化学式: C₁₀H₁₂FN₅O₄
• 分子量: 285.23
• InChiKey: HJQMFSDWWCLFTC-TWJUVVLDSA-N

物化性质

• 沸点：
  628.6±65.0 °C(Predicted)
• 密度：
  2.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

文献信息

• [18F]-furanosylpurine derivatives and uses thereof
  申请人：——

  公开号：US20040265232A1

  公开（公告）日：2004-12-30

  2′-Deoxy-2′-[ 18 F]-labeled and 3′-deoxy-3′-[ 18 F]-labeled purine nucleoside analogs such as [ 18 F]-FAA and [ 18 F]-FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [ 18 F]-FAA and [ 18 F]-FXA are also provided.

  2′-Deoxy-2′-&lsqb； 18 F]标记和 3′-脱氧-3′-[标记； 18 F]标记的嘌呤核苷类似物，如&lsqb； 18 F]-FAA和&lsqb； 18 F]-FXA 等嘌呤核苷类似物具有理想的成像特性。这些类似物特别适用于生物材料的体内成像，包括器官组织（如心脏、肝脏、大脑和肾脏）和肿瘤。制备 &lsqb； 18 F]-FAA和&lsqb； 18 F]-FXA 的制备方法。
• [18F]-FURANOSYLPURINE DERIVATIVES AND USES THEREOF
  申请人：Conti S. Peter

  公开号：US20080056988A1

  公开（公告）日：2008-03-06

  2′-Deoxy-2′-[ 18 F]-labeled and 3′-deoxy-3′-[ 18 F]-labeled purine nucleoside analogs such as [ 18 F]-FAA and [ 18 F]-FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [ 18 F]-FAA and [ 18 F]-FXA are also provided.
• US7273600B2
  申请人：——

  公开号：US7273600B2

  公开（公告）日：2007-09-25
• US8506926B2
  申请人：——

  公开号：US8506926B2

  公开（公告）日：2013-08-13
• [EN] [<18>F]-FURANOSYLPURINE DERIVATIVES AND USES THEREOF<br/>[FR] DERIVES DE [<18>F]-FURANOSYLPURINE ET LEURS UTILISATIONS
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2004096138A2

  公开（公告）日：2004-11-11

  2'-Deoxy-2'- [18F] -labeled and 3'-deoxy-3'- [18F] -labeled purine nucleoside analogs such as [18F]-FAA and [18F]­FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [18F]-FAA and [18F]-FXA are also provided.