6-(benzoyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole | 186543-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-(benzoyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole
• 英文别名: N-[6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]benzamide
• CAS: 186543-66-8
• 化学式: C₂₁H₂₃N₃O
• 分子量: 333.433
• InChiKey: KQRVIINFCSGRSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-(t-butoxy-carbonyl)amino-3-(dimethyl)amino-9-triisopropylsilyl-1,2,3,4-tetrahydro-9H-carbazole 在 ammonium hydroxide 、 硼酸 作用下， 以 四氢呋喃 为溶剂， 生成 6-(benzoyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole
  参考文献：
  名称：

  Methods of treating or ameliorating the symptoms of common cold or

  摘要：

  这项发明提供了治疗或改善普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种5-羟色胺5-HT.sub.1F激动剂。

  公开号：

  US05962473A1

文献信息

• Use of serotonin 5-HT1F agonists for the prevention of migraine
  申请人：ELI LILLY AND COMPANY

  公开号：EP0832650A3

  公开（公告）日：1998-09-02

  This invention provides methods for the prevention of migraine which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  这项发明提供了预防偏头痛的方法，包括向需要的哺乳动物施用一种5-HT1F受体激动剂。
• Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis
  申请人：ELI LILLY AND COMPANY

  公开号：EP0824917A3

  公开（公告）日：2000-08-30

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  这项发明提供了治疗或缓解普通感冒或过敏性鼻炎症状的方法，包括向需要的哺乳动物施用一种5-HT1F受体激动剂。
• 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and
  申请人：Eli Lilly and Company

  公开号：US05708187A1

  公开（公告）日：1998-01-13

  This invention provides novel 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta\x9b7,6-b!indoles. These compounds are 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.

  这项发明提供了新颖的6-取代-1,2,3,4-四氢-9H-咔唑和7-取代-10H-环庚\x9b7,6-b!吲哚。这些化合物是5-HT.sub.1F激动剂，对治疗偏头痛及相关疾病有用。
• Pharmaceutical method using 6-substituted-1, 2, 3,
  申请人：Eli Lilly and Company

  公开号：US05814653A1

  公开（公告）日：1998-09-29

  This invention provides novel 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta\x9b7,6-b!indoles. These compounds are 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.

  本发明提供了新型的6-取代-1,2,3,4-四氢-9H-咔唑和7-取代-10H-环庚[7,6-b]吲哚。这些化合物是5-HT.sub.1F激动剂，可用于治疗偏头痛和相关疾病。
• Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
  申请人：Eli Lilly and Company

  公开号：US06380201B1

  公开（公告）日：2002-04-30

  This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT1F agonist.

  本发明提供了一种治疗或缓解普通感冒或过敏性鼻炎症状的方法，包括向需要该治疗的哺乳动物施用一种5-羟色胺5-HT1F激动剂。