1-chloronon-1-en-4-one | 94397-56-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-chloronon-1-en-4-one
• CAS: 94397-56-5；94480-00-9
• 化学式: C₉H₁₅ClO
• 分子量: 174.671
• InChiKey: GIDVCUQKMPLAIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.28
• 重原子数：
  11.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  (1-氯丙-2-烯基)三甲基硅烷 、 己酰氯 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以85%的产率得到1-chloronon-1-en-4-one
  参考文献：
  名称：

  A NOVEL AND CONVENIENT REGIO-CONTROLLED SYNTHESIS OF α-HALOGEN-SUBSTITUTED ALLYLSILANES. STEREOSELECTIVE SYNTHESIS OF Z-ALKENYL HALIDES

  摘要：

  α-卤素取代的烯丙基硅烷是通过石化烯丙基卤化物与氯代硅烷以区域控制的方式发生原位反应而方便制备的。

  DOI：

  10.1246/cl.1984.1385

文献信息

• MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5HT 4 RECEPTORS
  申请人：Advanced Medicine, Inc.

  公开号：EP1102597A1

  公开（公告）日：2001-05-30
• [EN] MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5HT4 RECEPTORS<br/>[FR] AGONISTES MULTIVALENTS, AGONISTES PARTIELS, AGONISTES INVERSES ET ANTAGONISTES DES RECEPTEURS DE 5HT4
  申请人：ADVANCED MEDICINE INC

  公开号：WO1999064055A1

  公开（公告）日：1999-12-16

  Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT4 receptors, which are involved in gastrointestinal disorders. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an agonist, partial agonist, inverse agonist or antagonist of the 5HT4 receptors. The multibinding compounds of this invention are useful for the prophylaxis and treatment of various gastrointestinal disorders, central nervous disorders, cardiac function disorders, urinary disorders, and the like, as well as useful anti-nociceptors for analgesic use. Gastrointestinal disorders that can be treated using the compounds of this invention include gastroesophageal reflux disease (GERD), gastroparesis, functional dyspepsia, and irritable bowel syndrome.