3-甲基十五碳-1-烯-3-醇 | 88591-10-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-甲基十五碳-1-烯-3-醇
• 英文名称: 3-methyl-pentadec-1-en-3-ol
• 英文别名: 3-Methyl-pentadecen-(1)-ol-(3)；3-Methyl-pentadec-1-en-3-ol；3-Methylpentadec-1-EN-3-OL；3-methylpentadec-1-en-3-ol
• CAS: 88591-10-0
• 化学式: C₁₆H₃₂O
• 分子量: 240.429
• InChiKey: LPWMVIRBXLDVAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-甲基十五碳-1-烯-3-醇 在 甲醇 、 三溴化磷 、 铂 、 Petroleum ether 作用下， 生成 6-甲基-2-十八烷酮
  参考文献：
  名称：

  Weichet et al., Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 2754,2758

  摘要：

  DOI：
• 作为产物：
  描述：

  3-methyl-pentadec-1-yn-3-ol 生成 3-甲基十五碳-1-烯-3-醇
  参考文献：
  名称：

  Weichet et al., Collection of Czechoslovak Chemical Communications, 1957, vol. 22, p. 587,591

  摘要：

  DOI：

文献信息

• Bifunctional agents for reperfusion arrhythmias: Novel hybrid vitamin E/Class I antiarrhythmics
  作者：Maria Koufaki、Theodora Calogeropoulou、Eleni Rekka、Michael Chryselis、Panagiota Papazafiri、Catherine Gaitanaki、Alexandros Makriyannis

  DOI：10.1016/j.bmc.2003.08.010

  日期：2003.11

  We have synthesized a series of hybrid compounds combining the pharmacophoric redox moieties of vitamin E and key features responsible for the antiarrhythmic properties of the class I antiarrhythmics procainamide and lidocaine. Procainamide analogue (2a) and lidocaine analogues (14a) and (14b) are very strong inhibitors of lipid peroxidation. All analogues tested at 100 or 30 muM enhanced the post ischemic recovery without inducing ventricular fibrillations while there was no evidence in our experiments for drug-induced pro-arrhythmia. In addition, they induced a widening of the QRS intervals. Our data suggest that the efficacy of the new compounds in preventing reperfusion arrhythmias could be attributed to their combined effects involving inhibition of free radical mediated damage coupled with antiarrhythmic properties. (C) 2003 Elsevier Ltd. All rights reserved.
• Weichet et al., Collection of Czechoslovak Chemical Communications, 1957, vol. 22, p. 587,591
  作者：Weichet et al.

  DOI：——

  日期：——
• Weichet et al., Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 2754,2758
  作者：Weichet et al.

  DOI：——

  日期：——