2,6-dimethylmorpholine-4-carbohydrazide | 1094481-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2,6-dimethylmorpholine-4-carbohydrazide
• 英文别名: 2,6-Dimethyl-4-morpholinecarboxylic acid hydrazide
• CAS: 1094481-46-5
• 化学式: C₇H₁₅N₃O₂
• 分子量: 173.215
• InChiKey: DJYMEQQZKNTKOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methoxy-1H-imidazo[4,5-c]pyridin-2-amine 、 2,6-dimethylmorpholine-4-carbohydrazide 、 N,N'-硫羰基二咪唑 在 一水合肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(2,6-dimethylmorpholine-4-carbonyl)-N-(4-methoxy-3H-imidazo[4,5-c]pyridin-2-yl)hydrazine-1-carbothioamide
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS
  [FR] DÉRIVÉS D'IMIDAZOPYRIDINE ET D'OXAZOLOPYRIDINE ET LEURS ANALOGUES, LEURS PROCÉDÉS DE PRÉPARATION, PROCÉDÉS D'INHIBITION DE LA VOIE HIF-1/2A ET INDUCTION DE LA FERROPTOSE

  摘要：

  Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-1α and HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-1/2α or iron metabolism.

  公开号：

  WO2023234970A1
• 作为产物：
  描述：

  4-chlorocarbonyl-2,6-dimethylmorpholine 在 一水合肼 作用下， 以 1,4-二氧六环 为溶剂， 以7 g的产率得到2,6-dimethylmorpholine-4-carbohydrazide
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS
  [FR] DÉRIVÉS D'IMIDAZOPYRIDINE ET D'OXAZOLOPYRIDINE ET LEURS ANALOGUES, LEURS PROCÉDÉS DE PRÉPARATION, PROCÉDÉS D'INHIBITION DE LA VOIE HIF-1/2A ET INDUCTION DE LA FERROPTOSE

  摘要：

  Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-1α and HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-1/2α or iron metabolism.

  公开号：

  WO2023234970A1

文献信息

• [EN] IMIDAZOPYRIDINE AND OXAZOLOPYRIDINE DERIVATIVES AND ANALOGS THEREOF, METHODS OF PREPARATION THEREOF, METHODS OF HIF-1/2A PATHWAY INHIBITION, AND INDUCTION OF FERROPTOSIS<br/>[FR] DÉRIVÉS D'IMIDAZOPYRIDINE ET D'OXAZOLOPYRIDINE ET LEURS ANALOGUES, LEURS PROCÉDÉS DE PRÉPARATION, PROCÉDÉS D'INHIBITION DE LA VOIE HIF-1/2A ET INDUCTION DE LA FERROPTOSE
  申请人：[en]KUDA THERAPEUTICS, INC.

  公开号：WO2023234970A1

  公开（公告）日：2023-12-07

  Novel substituted imidazopyridine and oxazolopyridine compounds that are useful as inhibitors of HIF-1α and HIF-2α and inducers of ferroptosis through perturbations in iron metabolism, synthetic methods for making said compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions to treat disorders associated with dysfunction of HIF-1/2α or iron metabolism.