(E)-N-(2-methylpropyl)-3-iodoacrylamide | 110922-34-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-N-(2-methylpropyl)-3-iodoacrylamide
• 英文别名: (E)-3-iodo-N-(2-methylpropyl)prop-2-enamide
• CAS: 110922-34-4
• 化学式: C₇H₁₂INO
• 分子量: 253.083
• InChiKey: KIUQEHYMMYRGPT-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-N-(2-methylpropyl)-3-iodoacrylamide 在 bis(triphenylphosphine)palladium(0) Schwartz's reagent 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 (2E,4E)-N-(2-methylpropyl)undeca-2,4-dien-10-ynamide
  参考文献：
  名称：

  Hydrozirconation methods for natural isobutylamides (anacyclin, pellitorine and its vinylogue) and synthons.

  摘要：

  DOI：

  10.1016/s0040-4039(00)96649-8
• 作为产物：
  描述：

  (E)-N-(2-methylpropyl)-3-bromoacrylamide 在 三氯化铝 、 sodium iodide 作用下， 以 丙酮 为溶剂， 生成 (E)-N-(2-methylpropyl)-3-iodoacrylamide
  参考文献：
  名称：

  Hydrozirconation methods for natural isobutylamides (anacyclin, pellitorine and its vinylogue) and synthons.

  摘要：

  DOI：

  10.1016/s0040-4039(00)96649-8

文献信息

• Synthetic approaches to isobutylamides of insecticidal interest
  作者：Leslie Crombie、Mark A. Horsham、Robert J. Blade

  DOI：10.1016/s0040-4039(00)96650-4

  日期：1987.1

  Syntheses of 10,11-dehydro- and 10,11-()-pipercide, piperovatin, and an ene-yne, and a perfluoro-isobutylamide, illustrate the utility of hydrozirconation methodology in this area.

  10,11-脱氢和10,11-（）-哌啶，哌维丁，烯炔和全氟异丁酰胺的合成说明了氢化锆方法学在该领域的实用性。
• Pesticidal dihalovinylalkenylamides
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0228222A2

  公开（公告）日：1987-07-08

  A compound of Formula (I): (I) Q-X-(CH₂)c(CY=CY¹)dCONRR¹ wherein X is -CH₂- or -O- c = 0 to 10 d = 1 or 2 each of Y and Y¹ is independently selected from hydrogen, C1-4 alkyl and halo-­(C1-4) alkyl; R and R¹ are independently selected from hydrogen, alkyl, amino-alkyl, alkenyl, alkynyl and cycloalkyl, (any of which may be substituted by one or more of alkyl, alkenyl, alkynyl, alkoxy, halo, halo-alkyl and cyano), halo, cyano and dioxalanylalkyl, except that R¹ and R² are not both cyano or both halo; Q is alkoxy, cycloalkyl or branched alkyl (each optionally substituted by one or more of cycloalkenyl, phenyl, halo and cyano) or straight chain alkyl (substituted by one or more of alkynyl, halo or alkoxy) or alkynyl (optionally substituted by halo, cyano, trialkylsilyl, alkyl or cycloalkyl) or Q is a group (A): (A) R²-(CR³=CR⁴)a-(CH₂)b- in which a = 1 or 2 b = 0 to 4; and R², R³ and R⁴ are on each occurrence independently selected from hydrogen, cyano, halo, alkoxy, alkoxycarbonyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, alkyl (any of which may be optionally substituted by one or more of halo, alkoxy, cyano and alkoxy), acyl or a group -S(£0)n R⁵ where R⁵ is alkyl and n is 0 to 2, or alternatively R² and R³ or R³ and R⁴ together form part of an alicyclic 3 to 6 membered ring and the remainder of R² to R⁴ are as defined above.

  一种式(I)化合物： (I) Q-X-(CH₂)c(CY=CY¹)dCONRR¹ 其中 X 是 -CH₂- 或 -O- c = 0 至 10 d = 1 或 2 Y 和 Y¹ 各自独立选自氢、C1-4 烷基和卤代-(C1-4)烷基； R 和 R¹ 独立选自氢、烷基、氨基烷基、烯基、炔基和环烷基（其中任一环烷基可被一个或多个烷基、烯基、炔基、烷氧基、卤代、卤代烷基和氰基取代）、卤代、氰基和二噁烷基，但 R¹ 和 R² 不能同时为氰基或同时为卤代； Q 是烷氧基、环烷基或支链烷基（各自可选择被环烯基、苯基、卤代和氰基中的一个或多个取代）或直链烷基（被炔基、卤代或烷氧基中的一个或多个取代）或炔基（可选择被卤代、氰基、三烷基硅基、烷基或环烷基取代），或 Q 是基团 (A)： (A) R²-(CR³=CR⁴)a-(CH₂)b- 其中 a = 1 或 2 b = 0 至 4；以及 R²、R³ 和 R⁴ 在每次出现时均独立地选自氢、氰基、卤代、烷氧基、烷氧羰基、环烷基、环烯基、烯基、炔基、烷基（其中任一烷基可任选被卤代、烷氧基、氰基和烷氧基中的一个或多个取代）、酰基、环烷基、环烯基、炔基、烷基（其中任一烷基可任选被卤代、烷氧基、氰基和烷氧基中的一个或多个取代）、R⁵为烷基且 n 为 0 至 2，或 R² 和 R³ 或 R³ 和 R⁴ 共同构成脂环族 3 至 6 位环的一部分，且 R² 至 R⁴ 的其余部分如上定义。
• Stereoselective Synthesis of Naturally-Occurring 7-(Hetero) Aryl (2E, 4E, 6E)-2, 4, 6-Heptatrienamides and Their Structural Analogues
  作者：Renzo Rossi、Adriano Carpita、Vito Lippolis

  DOI：10.1080/00397919108016755

  日期：1991.2

  A new and efficient highly stereoselective method to prepare naturally-occurring 7-(hetero)aryl (2E,4E,6E)-2,4,6-heptatrienamides and their structural analogues has been developed. The physical and spectral properties of one of these compounds, i.e. (2E,4E,6E)-7-(2-thienyl)-2,4,6-heptatrienoic acid piperidide (4 b), have been found to be quite different from those previously reported for 7-(2-thienyl)-2,4,6-heptatrienoic acid piperidide isolated from Othantus maritimus to which the (2E,4E,6E)-configuration had been previously assigned.
• Rossi, Renzo; Carpita, Adriano; Lippolis, Vito, Gazzetta Chimica Italiana, 1990, vol. 120, p. 783 - 791
  作者：Rossi, Renzo、Carpita, Adriano、Lippolis, Vito、Benetti, Massimo

  DOI：——

  日期：——
• ROSSI, RENZO;CARPITA, ADRIANO;LIPPOLIS, VITO;BENETTI, MASSIMO, GAZZ. CHIM. ITAL., 120,(1990) N2, C. 783-791
  作者：ROSSI, RENZO、CARPITA, ADRIANO、LIPPOLIS, VITO、BENETTI, MASSIMO

  DOI：——

  日期：——