A-Lactulose | 85026-53-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: A-Lactulose
• 英文别名: (2S,3S,4R,5R)-2-(hydroxymethyl)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2,3,5-triol
• CAS: 85026-53-5
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: NBGXQZRRLOGAJF-WJONTELPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• Derivatives of polyene macrolides and preparation and use thereof
  申请人：——

  公开号：US20020094961A1

  公开（公告）日：2002-07-18

  The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.

  本发明提供了一类新的多烯大环内酯衍生物，可用于治疗或预防真菌感染。与两性霉素 B 甲酯（AME）相比，新的多烯大环内酯衍生物表现出惊人的抗真菌活性和水溶性。此外，与两性霉素 B（AmB）和 AME 相比，新型多烯大环内酯衍生物的水溶性更好，毒性更低。
• DERIVATIVES OF POLYENE MACROLIDES AND PREPARATION AND USE THEREOF
  申请人：IntraBiotics Pharmaceuticals, Inc.

  公开号：EP1278527A1

  公开（公告）日：2003-01-29
• EP1278527A4
  申请人：——

  公开号：EP1278527A4

  公开（公告）日：2003-04-09
• US6562796B2
  申请人：——

  公开号：US6562796B2

  公开（公告）日：2003-05-13
• [EN] DERIVATIVES OF POLYENE MACROLIDES AND PREPARATION AND USE THEREOF<br/>[FR] DERIVES DE MACROLIDES DE POLYENE, PREPARATION ET UTILISATIONS CORRESPONDANTES
  申请人：INTRABIOTICS PHARMACEUTICALS

  公开号：WO2001051061A1

  公开（公告）日：2001-07-19

  The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.