(2R,3S,4S,5R,6S)-4-Allyloxy-2-allyloxymethyl-3,5,6-tris-benzyloxy-tetrahydro-pyran | 63070-10-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R,6S)-4-Allyloxy-2-allyloxymethyl-3,5,6-tris-benzyloxy-tetrahydro-pyran
• 英文别名: (2S,3R,4S,5S,6R)-2,3,5-tris(phenylmethoxy)-4-prop-2-enoxy-6-(prop-2-enoxymethyl)oxane
• CAS: 63070-10-0
• 化学式: C₃₃H₃₈O₆
• 分子量: 530.661
• InChiKey: YJFPCUBSFMROCU-CYEGLCQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  39
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Oligosaccharide, method for producing it and pharmaceutical composition containing it
  申请人：Seikagaku Corporation

  公开号：EP1018515A1

  公开（公告）日：2000-07-12

  A method for producing oligosaccharides, including those usable as anti-inflammatory agent or anti-allergy agent, represented by the following general formula (3): wherein R10 and R11 each independently represent a hydrogen atom or -SO3M where M represents a proton or a monovalent cation, Ac represents an acetyl group, R12 represents a hydrogen atom or an anomeric substituent (a 6-O-sulfated N-acetylglucosamine residue, an alkyl group, a glycerol residue, an O-alkylglycerol residue, a cholesterol residue, a cholestanyl group, a ceramide residue, a phospholipid residue, a biotin residue, or a peptide residue), and Z represents an oxygen atom or -NHCO-,    which method comprises at least a step of carrying out glycosidic linkage formation between a monosaccharide represented by the following general formula (1): wherein R1 and R2 each independently represent an aralkyl group, R3 represents an acyl group or a silyl group, R4 represents a protective group for an amino group, and R5 represents a leaving group, and    a monosaccharide represented by the following general formula (2): wherein R6 and R8 each independently represent an aralkyl group, R7 represents an acyl group or a silyl group, R9 represents an aralkyl group or the anomeric substituent, and Z is as defined above.

  一种生产由以下通式(3)代表的低聚糖，包括可用作抗炎剂或抗过敏剂的低聚糖的方法： 其中 R10 和 R11 各自独立地代表氢原子或-SO3M，其中 M 代表质子或一价阳离子，Ac 代表乙酰基，R12 代表氢原子或异构取代基（6-O-硫酸化的 N-乙酰氨基葡萄糖残基、烷基、甘油残基、O-烷基甘油残基、胆固醇残基、胆甾烷基、神经酰胺残基、磷脂残基、生物素残基或肽残基），Z 代表氧原子或-NHCO-、 该方法至少包括以下通式（1）所代表的单糖之间形成糖苷键的步骤： 其中 R1 和 R2 各自独立地代表芳烷基，R3 代表酰基或硅烷基，R4 代表氨基的保护基，R5 代表离去基团，以及 由以下通式（2）代表的单糖： 其中 R6 和 R8 各自独立地代表一个芳烷基，R7 代表一个酰基或硅烷基，R9 代表一个芳烷基或异构取代基，Z 如上所定义。
• US6562954B1
  申请人：——

  公开号：US6562954B1

  公开（公告）日：2003-05-13