3-[1-(4-aminobutyl)-1H-imidazole-4-yl]-phenylamine | 1044930-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[1-(4-aminobutyl)-1H-imidazole-4-yl]-phenylamine
• 英文别名: 3-[1-(4-Aminobutyl)imidazol-4-yl]aniline
• CAS: 1044930-05-3
• 化学式: C₁₃H₁₈N₄
• 分子量: 230.313
• InChiKey: BLOIKPWSTSSJRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[1-(4-aminobutyl)-1H-imidazole-4-yl]-phenylamine 、 Telithromycin intermediate (7A) 以 水 、 乙腈 为溶剂， 反应 14.0h， 生成
  参考文献：
  名称：

  WO2006/129257

  摘要：

  公开号：

文献信息

• Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens
  作者：Rajesh Kumar、Sujata Rathy、Atul K. Hajare、Yogesh B. Surase、Jyoti Dullu、Jitendra S. Jadhav、R. Venkataramanan、Anjan Chakrabarti、Manisha Pandya、Pragya Bhateja、G. Ramkumar、Biswajit Das

  DOI：10.1016/j.bmcl.2011.10.101

  日期：2012.1

  A novel series of acylides 4 were designed to overcome antibacterial resistance and evaluated for in vitro and in vivo activity. This series of acylides was designed from clarithromycin by changing the substitution on the desosamine nitrogen, followed by conversion to 3-O-acyl and 11,12-carbamate. These compounds showed significantly potent antibacterial activity against not only Gram-positive pathogens, including macrolide-lincosamide-streptogramin B (MLSB)-resistant and efflux-resistant strains, but also Gram-negative pathogens such as Haemophilus influenzae. These acylides also showed better activity against telithromycin resistant Streptococcus pneumoniae strains. (C) 2011 Elsevier Ltd. All rights reserved.
• [EN] KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES DE CETOLIDES UTILISES COMME AGENTS ANTIBACTERIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2006129257A2

  公开（公告）日：2006-12-07

  [EN] The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.
  [FR] La présente invention porte sur des dérivés de cétolides qui peuvent être utilisés comme agents antibactériens. Les composés de cette invention peuvent en particulier être utilisés dans le traitement ou la prévention d'états causés ou favorisés par des bactéries gram positif, gram négatif ou anaérobies, plus particulièrement, par exemple, contre les staphylocoques, streptocoques, entérocoques, l'hémophilus, Moraxalla spp., Chlamydia spp., mycoplasme, Legionella spp., mycobactérium, Helicobacter, Clostridium, bactéroïdes, Corynebacterium, bacille ou entérobacteriacée. Cette invention porte également sur des procédés de préparation de ces dérivés de cétolides, sur des compositions pharmaceutiques de ceux-ci et sur des méthodes de traitement d'infections bactériennes.