4-Acetyl-2-fluorthiophen | 32415-48-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Acetyl-2-fluorthiophen
• 英文别名: 1-(5-fluoro-thiophen-3-yl)-ethanone；1-(5-Fluorothiophen-3-yl)ethanone
• CAS: 32415-48-8
• 化学式: C₆H₅FOS
• 分子量: 144.17
• InChiKey: AKJJKTWKLHLGNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR PREPARATION OF SUBSTITUTED AROMATIC COMPOUND
  申请人：——

  公开号：US20020161227A1

  公开（公告）日：2002-10-31

  A substituted aromatic compound substituted with Q is obtained by reacting a phosphazenium compound represented by formula (1) 1 (in the formula, Q − represents an anion in a form derived by elimination of a proton from an inorganic acid, or an active hydrogen compound having an active hydrogen on an oxygen atom, a nitrogen atom or a sulfur atom; a, b, c and d, each independently, is 0 or 1, but all of them are not 0 simultaneously; and R groups represent the same or different hydrocarbon groups having 1 to 10 carbon atoms, or two Rs on each common nitrogen atom may be bonded together to form a ring structure) with a halogenated aromatic compound having halogen atoms; whereby, at least one halogen atom in the halogenated aromatic compound is substituted with Q (where, Q represents an inorganic group or an organic group in a form derived by elimination of one electron from Q − in formula (1)).

  通过将式（1）1所代表的磷氮化合物与含有卤原子的芳香化合物反应，可以得到一种被Q取代的取代芳香化合物（其中，Q-在公式中代表从无机酸中去除质子或具有氧原子、氮原子或硫原子上的活性氢的活性氢化合物所导出的形式的阴离子；a、b、c和d各自独立地为0或1，但它们不同时为0；R基表示具有1至10个碳原子的相同或不同的碳氢基团，或者在每个共同氮原子上的两个R可能被结合在一起形成环状结构）。因此，至少有一个卤原子被Q取代（其中，Q在公式（1）中代表从Q-中去除一个电子所导出的无机基团或有机基团）。
• PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1275630A1

  公开（公告）日：2003-01-15

  A substituted aromatic compound substituted with Q is obtained by reacting a phosphazenium compound represented by formula (1) (in the formula, Q- represents an anion in a form derived by elimination of a proton from an inorganic acid, or an active hydrogen compound having an active hydrogen on an oxygen atom, a nitrogen atom or a sulfur atom; a, b, c and d, each independently, is 0 or 1, but all of them are not 0 simultaneously; and R groups represent the same or different hydrocarbon groups having 1 to 10 carbon atoms, or two Rs on each common nitrogen atom may be bonded together to form a ring structure) with a halogenated aromatic compound having halogen atoms; whereby, at least one halogen atom in the halogenated aromatic compound is substituted with Q (where, Q represents an inorganic group or an organic group in a form derived by elimination of one electron from Q- in formula (1)).

  将式(1)代表的鏻化合物与 Q 取代的取代芳香族化合物反应，可获得取代芳香族化合物 式中 Q- 代表通过从无机酸中消除质子而得到的阴离子，或在氧原子、氮原子或硫原子上具有活泼氢的活泼氢化合物； a、b、c 和 d 各自独立地为 0 或 1，但它们同时都不是 0；以及 R 基团代表具有 1 至 10 个碳原子的相同或不同的烃基，或每个公共氮原子上的两个 R 可键合在一起形成环结构）与具有卤素原子的卤代芳香族化合物；其中，卤代芳香族化合物中的至少一个卤素原子被以下物质取代 Q (其中，Q 代表无机基团或有机基团，其形式是通过消除式（1）中 Q- 的一个电子而得到的）。
• US6469224B1
  申请人：——

  公开号：US6469224B1

  公开（公告）日：2002-10-22

表征谱图