H-D-Ser-D-Asn-D-Asn-D-Phe-OGly-D-Ala-D-OIle-D-Leu-OGly-D-Ser-NH2 | 1007595-83-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: H-D-Ser-D-Asn-D-Asn-D-Phe-OGly-D-Ala-D-OIle-D-Leu-OGly-D-Ser-NH2
• 英文别名: [2-[[(2R)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl] (2R)-2-[[(2R,3R)-2-[(2R)-2-[[2-[(2R)-2-[[(2R)-4-amino-2-[[(2R)-4-amino-2-[[(2R)-2-amino-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]oxyacetyl]amino]propanoyl]oxy-3-methylpentanoyl]amino]-4-methylpentanoate
• CAS: 1007595-83-6
• 化学式: C₄₂H₆₄N₁₀O₁₇
• 分子量: 981.027
• InChiKey: ZOSASVBNDHVJND-YWNSBGQCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  69
• 可旋转键数：
  34
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  449
• 氢给体数：
  12
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  (2R,3R)-2-(((((9H-fluoren-9-yl)methoxy)carbonyl)-D-alanyl)oxy)-3-methylpentanoic acid 、 Fmoc-D-亮氨酸 、 Fmoc-D-丝氨酸 、 Fmoc-D-苯丙氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 H-D-Ser-D-Asn-D-Asn-D-Phe-OGly-D-Ala-D-OIle-D-Leu-OGly-D-Ser-NH2
  参考文献：
  名称：

  Mirror image supramolecular helical tapes formed by the enantiomeric-depsipeptide derivatives of the amyloidogenic peptide amylin(20–29)

  摘要：

  Factors that determine the chirality of supramolecular helical tapes formed by a backbone-modified amylin(20-29) depsipeptide and inverso-depsipeptide, were studied by Fourier transform infrared spectroscopy, circular dichroism and transmission electron microscopy. Although P-sheet propensity was absent in both peptides, it was found that the L-depsipeptide formed left-handed and the enantiomeric D-depsipeptide right-handed helical tapes. Moreover, the backbone-modified depsipeptides, showed a certain degree of cross-recognition between both enantiomers, which might have implications in designing amyloid formation inhibitors. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.021