4-[(4-chloro-phenyl)-phenyl-methyl]-naphthalen-1-ol | 956702-84-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-[(4-chloro-phenyl)-phenyl-methyl]-naphthalen-1-ol
• CAS: 956702-84-4
• 化学式: C₂₃H₁₇ClO
• 分子量: 344.84
• InChiKey: WIXUETHLQPVIIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.38
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  4-[(4-chloro-phenyl)-phenyl-methyl]-naphthalen-1-ol 、 2-(环己亚氨基)乙基氯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.0h， 以69%的产率得到1-[2-[[4-[(4-Chlorophenyl)-phenyl-methyl]-1-naphthyl]oxy]ethyl]azepane
  参考文献：
  名称：

  Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives

  摘要：

  A new series of diarylmethylnapthyloxy ethylamines were synthesized by antinoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Rv, in vitro and showed MIC in the range of 3.12-25 mu g/ml. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.089
• 作为产物：
  描述：

  萘酚 、 4-氯二苯甲醇 在 硫酸 作用下， 以 苯 为溶剂， 反应 2.0h， 以70%的产率得到4-[(4-chloro-phenyl)-phenyl-methyl]-naphthalen-1-ol
  参考文献：
  名称：

  Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives

  摘要：

  A new series of diarylmethylnapthyloxy ethylamines were synthesized by antinoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Rv, in vitro and showed MIC in the range of 3.12-25 mu g/ml. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.089